Erik Wambre

TL;DR: In this paper, the authors identified at least two highly promiscuous major histocompatibility complex class II T-cell epitopes in the Fc fragment of IgG that are capable of specifically activating CD4+CD25HiFoxP3+ natural regulatory T cells (nTRegs).

TL;DR: In this model, regulatory T-cell epitopes in IgG activate a subset of nT(Regs) that tips the resulting immune response toward tolerance rather than immunogenicity, suggesting one mechanism for the immunosuppressive activity of IgG may be related to the activity of regulatory T cells.

TL;DR: In this paper, a subset of human memory T H 2 cells confined to atopic individuals were identified, which are terminally differentiated CD4 + T cells (CD27 − and CD45RB − ) characterized by coexpression of CRT H 2, CD49d, and CD161.

TL;DR: Restoration of a protective response during SIT appears to be due to the preferential deletion of pathogenic (CD27(-)) allergen-specific CD4(+) T cells accompanied by IL-10 induction in surviving CD27(+) aller Genetically modified T cells.

TL;DR: The tremendous dynamics of T cell responses in both allergic and nonallergic individuals during the peak pollen season are demonstrated, with an expansion of Bet v 1-specific precursors from 10−6 to 10−3 among circulating CD4+ T lymphocytes.