Philippe Moingeon

TL;DR: A core peripheral blood immune signature is identified across 63 hospital-treated patients with COVID-19 who were otherwise highly heterogeneous and sheds light into the pathogenesis and clinical progression of the disease.

TL;DR: In this paper, the authors identified at least two highly promiscuous major histocompatibility complex class II T-cell epitopes in the Fc fragment of IgG that are capable of specifically activating CD4+CD25HiFoxP3+ natural regulatory T cells (nTRegs).

TL;DR: In this model, regulatory T-cell epitopes in IgG activate a subset of nT(Regs) that tips the resulting immune response toward tolerance rather than immunogenicity, suggesting one mechanism for the immunosuppressive activity of IgG may be related to the activity of regulatory T cells.

TL;DR: Second‐generation vaccines based on recombinant allergens in a native conformation formulated with adjuvants are designed to target Langerhans‐like cells in the sublingual mucosa, with the aim to induce allergen‐specific regulatory T cells to facilitate the identification of biological markers of SLIT efficacy in humans.

TL;DR: Findings show that a cellular pool of Fc gamma RII/III+ precursors gives rise to T and NK lineages in a microenvironment-dependent manner and suggest a hitherto unrecognized role for Fc receptors on primitive T cells.