C
Chester Ni
Researcher at Benaroya Research Institute
Publications - 14
Citations - 1024
Chester Ni is an academic researcher from Benaroya Research Institute. The author has contributed to research in topics: Virus & T cell. The author has an hindex of 11, co-authored 14 publications receiving 859 citations. Previous affiliations of Chester Ni include University of Washington & Merck & Co..
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Journal ArticleDOI
A phenotypically and functionally distinct human TH2 cell subpopulation is associated with allergic disorders
Erik Wambre,Veronique Bajzik,Jonathan H. DeLong,Kimberly O’Brien,Quynh-Anh Nguyen,Cate Speake,Vivian H. Gersuk,Hannah A. DeBerg,Elizabeth Whalen,Chester Ni,Mary L. Farrington,David Jeong,David Robinson,Peter S. Linsley,Brian P. Vickery,William W. Kwok,William W. Kwok +16 more
TL;DR: In this paper, a subset of human memory T H 2 cells confined to atopic individuals were identified, which are terminally differentiated CD4 + T cells (CD27 − and CD45RB − ) characterized by coexpression of CRT H 2, CD49d, and CD161.
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MicroRNA Expression and Virulence in Pandemic Influenza Virus-Infected Mice
Yu Li,Eric Y. Chan,Jiangning Li,Chester Ni,Xinxia Peng,Elizabeth Rosenzweig,Terrence M. Tumpey,Michael G. Katze +7 more
TL;DR: This is the first demonstration that cellular gene expression patterns in influenza virus-infected mice may be attributed in part to microRNA regulation and that such regulation may be a contributing factor to the extreme virulence of the r1918.
Journal ArticleDOI
In Active Relapsing-Remitting Multiple Sclerosis, Effector T Cell Resistance to Adaptive T regs Involves IL-6-Mediated Signaling
Anya Schneider,S. A. Long,Karen Cerosaletti,Chester Ni,Peter L. Samuels,Mariko Kita,Jane H. Buckner +6 more
TL;DR: It is reported that some Teffs are resistant to Tregs in patients with active relapsing-remitting multiple sclerosis (RRMS) and that this resistance is dependent on interleukin-6 (IL-6) signaling.
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Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers
I-Ming Wang,Bin Zhang,Xia Yang,Xia Yang,Jun Zhu,Serguei Stepaniants,Chunsheng Zhang,Qingying Meng,Mette A. Peters,Yudong D. He,Chester Ni,Deborah Slipetz,Michael A. Crackower,Hani Houshyar,Christopher M. Tan,Ernest Asante-Appiah,Gary P. O'Neill,Mingjuan Jane Luo,Rolf Thieringer,Jeffrey Yuan,Chi-Sung Chiu,Pek Yee Lum,John Lamb,Yves Boie,Hilary A. Wilkinson,Eric E. Schadt,Hongyue Dai,Christopher Michael Roberts +27 more
TL;DR: The identification of this inflammatome signature, its network architecture, and key drivers not only highlights the shared etiology but also pinpoints potential targets for intervention of various common diseases.
Journal ArticleDOI
Lethal Dissemination of H5N1 Influenza Virus Is Associated with Dysregulation of Inflammation and Lipoxin Signaling in a Mouse Model of Infection
Cristian Cilloniz,Mary J. Pantin-Jackwood,Chester Ni,Alan G. Goodman,Xinxia Peng,Sean Proll,Victoria S. Carter,Elizabeth Rosenzweig,Kristy J. Szretter,Jacqueline M. Katz,Marcus J. Korth,David E. Swayne,Terrence M. Tumpey,Michael G. Katze +13 more
TL;DR: It is suggested that Vietnam/1203 is more pathogenic in mice as a consequence of several factors, including the early and sustained induction of the inflammatory response, the additive or synergistic effects of upregulated components of the immune response, and inhibition of lipoxin-mediated anti-inflammatory responses, which correlated with the ability of VN/ 1203 to disseminate to extrapulmonary organs.