Ernesto Guccione

TL;DR: SIRT6 is identified as a tumor suppressor that regulates aerobic glycolysis in cancer cells and functions as a regulator of ribosome metabolism by corepressing MYC transcriptional activity, highlighting SIRT6 as a critical modulator of cancer metabolism.

TL;DR: In this paper, the authors identify SIRT6 as a tumor suppressor that regulates aerobic glycolysis in cancer cells, and they show that deletion of SIRT 6 allele increases the number, size, and aggressiveness of tumors.

TL;DR: It is shown that the arginine methyltransferase PRMT6 catalyses H3R2 di-methylation in vitro and controls global levels of H 3R2me2a in vivo, and that the mutual antagonism between H2R2 and H3K4 methylation, together with the association of MLL-family complexes with the basal transcription machinery, may contribute to the localized patterns of H3k4 tri-methylated promoters in mammalian genomes.

TL;DR: The results indicate that Myc activates and represses transcription of discrete gene sets, leading to changes in cellular state that can in turn feed back on global RNA production and turnover.

TL;DR: The correlations between 35 histone marks and genomic binding by the transcription factor Myc imply that tethering of a transcription factor to restricted chromatin domains is rate-limiting for sequence-specific DNA binding in vivo.