E
Erwin G. Van Meir
Researcher at University of Alabama at Birmingham
Publications - 202
Citations - 39049
Erwin G. Van Meir is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Glioma & Cancer. The author has an hindex of 75, co-authored 183 publications receiving 32866 citations. Previous affiliations of Erwin G. Van Meir include Emory University & University Hospital of Lausanne.
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Journal ArticleDOI
Epidermal growth factor receptor and PTEN modulate tissue factor expression in glioblastoma through JunD/activator protein-1 transcriptional activity.
Yuan Rong,Vladimir E. Belozerov,Carol Tucker-Burden,Gang Chen,Donald L. Durden,Jeffrey J. Olson,Erwin G. Van Meir,Nigel Mackman,Daniel J. Brat +8 more
TL;DR: It is shown that overexpression of EGfr or EGFRvIII in human glioma cells causes increased basal TF expression and that stimulation of EGFR by its ligand, EGF, leads to a marked dose-dependent up-regulation of TF, which led to accelerated plasma coagulation in vitro.
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Noscapine Crosses the Blood-Brain Barrier and Inhibits Glioblastoma Growth
Jaren W. Landen,Vincent S. Hau,Mingshen Wang,Thomas P. Davis,Brian J. Ciliax,Bruce H. Wainer,Erwin G. Van Meir,Johnathan D. Glass,Harish C. Joshi,David R. Archer +9 more
TL;DR: It is shown that noscapine inhibits the proliferation of rat C6 glioma cells in vitro and effectively crosses the blood-brain barrier at rates similar to the ones found for agents such as morphine and [Met]enkephalin that have potent central nervous system activity.
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Hypoxia inducible factor-1: a novel target for cancer therapy.
TL;DR: This work highlights some of the recently developed small-molecule inhibitors of HIF-1 function, which disrupt the H IF-1 signaling pathway through a variety of mechanisms, including the inhibition of Hif-1&agr; protein synthesis, stabilization, nuclear translocation and HIF1 transactivation of target genes.
Journal Article
The PTEN Lipid Phosphatase Domain Is Not Required to Inhibit Invasion of Glioma Cells
Daniel Maier,Graham Jones,Xinwei Li,Axel H. Schönthal,Otmar Gratzl,Erwin G. Van Meir,Adrian Merlo +6 more
TL;DR: It is concluded that phosphatase-independent domains of PTEN markedly reduced the invasive potential of glioma cells, defining a structural role for PTEN that regulates cell motility distinct of the PKB/Akt pathway.
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Brain cancer propagating cells: biology, genetics and targeted therapies
TL;DR: Treatments that include specific targeting of BCPCs might potentially be more effective at treating the entire tumor mass, translating to improved patient survival and quality of life.