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Esben Lorentzen
Researcher at Aarhus University
Publications - 79
Citations - 5787
Esben Lorentzen is an academic researcher from Aarhus University. The author has contributed to research in topics: Intraflagellar transport & Cilium. The author has an hindex of 34, co-authored 71 publications receiving 4828 citations. Previous affiliations of Esben Lorentzen include Birkbeck, University of London & Max Planck Society.
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Journal ArticleDOI
Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases
Martin Steger,Francesca Tonelli,Genta Ito,Paul Davies,Matthias Trost,Melanie Vetter,Stefanie Wachter,Esben Lorentzen,Graham Duddy,Stephen S. Wilson,Marco A. S. Baptista,Brian K. Fiske,Matthew J. Fell,John A. Morrow,Alastair D. Reith,Dario R. Alessi,Matthias Mann +16 more
TL;DR: This work employs a combination of phosphoproteomics, genetics, and pharmacology to unambiguously identify a subset of Rab GTPases as key LRRK2 substrates and a novel regulatory mechanism of Rabs that connects them to PD.
Journal ArticleDOI
A single subunit, Dis3, is essentially responsible for yeast exosome core activity.
TL;DR: It is observed that the yeast exosome ring mediates interactions with protein partners, providing an explanation for its essential function.
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The Crystal Structure of the Exon Junction Complex Reveals How It Maintains a Stable Grip on mRNA
TL;DR: Comparison with the structure of the eIF4AIII-Btz subcomplex that is determined reveals that large conformational changes are required upon EJC assembly and disassembly.
Journal ArticleDOI
Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis
Martin Steger,Federico Diez,Herschel S. Dhekne,Pawel Lis,Raja Sekhar Nirujogi,Ozge Karayel,Francesca Tonelli,Terina N. Martinez,Esben Lorentzen,Suzanne R. Pfeffer,Dario R. Alessi,Matthias Mann +11 more
TL;DR: The results implicate LRRK2 in primary ciliogenesis and suggest that Rab-mediated protein transport and/or signaling defects at cilia may contribute to L RRK2-dependent pathologies.
Journal ArticleDOI
Molecular Basis of Tubulin Transport Within the Cilium by IFT74 and IFT81
Sagar Bhogaraju,Lukas Cajanek,Cécile Fort,Thierry Blisnick,Kristina Weber,Michael Taschner,Naoko Mizuno,Stefan Lamla,Philippe Bastin,Erich A. Nigg,Esben Lorentzen +10 more
TL;DR: Intraflagellar transport of ciliary precursors such as tubulin from the cytoplasm to the ciliary tip is involved in the construction of the cilium, a hairlike organelle found on most eukaryotic cells, but the molecular mechanisms of IFT are poorly understood.