Esther Pueyo

TL;DR: It is argued that the second enabling pillar towards this vision is the increasing power of computers and algorithms to learn, reason, and build the ‘digital twin’ of a patient.

TL;DR: A new method is proposed to evaluate the dynamics of QT interval adaptation in response to heart rate (HR) changes, discriminating between post-myocardial infarction patients at high and low risk of arrhythmic death while on treatment with amiodarone.

TL;DR: Abnormalities in repolarization and its rate dependence are known to be related to increased proarrhythmic risk, and a number of repolarisation-related electrophysiological properties are commonly used as discussed by the authors.

TL;DR: A combined approach of assessing multiple ion channels, along with ECG intervals and T wave morphology may provide the greatest insight into drug‐ion channel interactions and torsade de pointes risk.

TL;DR: Investigation of the role of intrinsic and extrinsic noise in I(Ks) in modulating temporal and spatial variability in ventricular repolarization in human and guinea pig shows that under physiological conditions, stochastic fluctuations in I-Ks gating properties cause significant beat-to-beat variability in action potential duration (APD) in isolated cells, whereas cell- to-cell differences in channel numbers contribute to cell-To-cell APD differences.