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Ethan D. Buhr
Researcher at University of Washington
Publications - 47
Citations - 8456
Ethan D. Buhr is an academic researcher from University of Washington. The author has contributed to research in topics: Circadian rhythm & Circadian clock. The author has an hindex of 23, co-authored 43 publications receiving 7340 citations. Previous affiliations of Ethan D. Buhr include University of Texas Southwestern Medical Center & Northwestern University.
Papers
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Journal ArticleDOI
PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues
Seung Hee Yoo,Shin Yamazaki,Shin Yamazaki,Phillip L. Lowrey,Kazuhiro Shimomura,Caroline H. Ko,Caroline H. Ko,Ethan D. Buhr,Sandra M. Siepka,Hee Kyung Hong,Won Jun Oh,Ook Joon Yoo,Michael Menaker,Joseph S. Takahashi +13 more
TL;DR: It is demonstrated that peripheral tissues express self-sustained, rather than damped, circadian oscillations and the existence of organ-specific synchronizers of circadian rhythms at the cell and tissue level is suggested.
Journal ArticleDOI
Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes
Biliana Marcheva,Kathryn Moynihan Ramsey,Ethan D. Buhr,Yumiko Kobayashi,Hong Su,Caroline H. Ko,Ganka Ivanova,Chiaki Omura,Shelley Mo,Martha Hotz Vitaterna,James P. Lopez,Louis H. Philipson,Christopher A. Bradfield,Seth D. Crosby,Lellean JeBailey,Xiaozhong Wang,Joseph S. Takahashi,Joseph Bass +17 more
TL;DR: A role for the β-cell clock is demonstrated in coordinating insulin secretion with the sleep–wake cycle, and ablation of the pancreatic clock can trigger the onset of diabetes mellitus.
Journal ArticleDOI
Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD+ Biosynthesis
Kathryn Moynihan Ramsey,Jun Yoshino,Cynthia S. Brace,Dana Abrassart,Yumiko Kobayashi,Yumiko Kobayashi,Biliana Marcheva,Hee Kyung Hong,Jason L. Chong,Ethan D. Buhr,Choogon Lee,Joseph S. Takahashi,Shin-ichiro Imai,Joseph Bass,Joseph Bass +14 more
TL;DR: It is reported that both the rate-limiting enzyme in mammalian Nicotinamide adenine dinucleotide (NAD+) biosynthesis, nicotinamide phosphoribosyltransferase (NAMPT), and levels of NAD+ display circadian oscillations that are regulated by the core clock machinery in mice.
Book ChapterDOI
Molecular components of the Mammalian circadian clock
TL;DR: This work has shown that there are other molecular circadian oscillators which can act independently of the transcription-based clock in all species which have been tested.
Journal ArticleDOI
Temperature as a Universal Resetting Cue for Mammalian Circadian Oscillators
TL;DR: It is reported here that resistance to temperature entrainment is a property of the suprachiasmatic nucleus (SCN), a region of the mammalian brain that functions as the body's master clock, and is not a cell-autonomous property of mammalian clocks.