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Etsuko Tanji
Researcher at American Hotel & Lodging Educational Institute
Publications - 11
Citations - 695
Etsuko Tanji is an academic researcher from American Hotel & Lodging Educational Institute. The author has contributed to research in topics: Pancreas & Medicine. The author has an hindex of 6, co-authored 8 publications receiving 586 citations.
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Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas
Toru Furukawa,Yuko Kuboki,Etsuko Tanji,Shoko Yoshida,Takashi Hatori,Masakazu Yamamoto,Noriyuki Shibata,Kyoko Shimizu,Naoyuki Kamatani,Keiko Shiratori +9 more
TL;DR: Results indicate that GNAS mutations are common and specific for IPMN, and activation of G-protein signaling appears to play a pivotal role in IPMN.
Journal ArticleDOI
GNAS R201H and Kras G12D cooperate to promote murine pancreatic tumorigenesis recapitulating human intraductal papillary mucinous neoplasm
Katsunobu Taki,Masaki Ohmuraya,Etsuko Tanji,Hirotake Komatsu,Daisuke Hashimoto,Kei Semba,Kimi Araki,Y. Kawaguchi,Hideo Baba,Toru Furukawa +9 more
TL;DR: The data strongly suggest that activating mutations in GNAS and Kras cooperatively promote murine pancreatic tumorigenesis, which recapitulates IPMN, and may serve as a unique in vivo platform to find biomarkers and effective drugs for diseases associated with GNAS mutations.
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MicroRNAs Associated with Mitogen-Activated Protein Kinase in Human Pancreatic Cancer
TL;DR: Results indicate that activation of MAPK may play a significant role in aberrant expression of miRNAs and their associated phenotypes in pancreatic cancer.
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A GNAS Mutation Found in Pancreatic Intraductal Papillary Mucinous Neoplasms Induces Drastic Alterations of Gene Expression Profiles with Upregulation of Mucin Genes
Hirotake Komatsu,Etsuko Tanji,Naoaki Sakata,Takeshi Aoki,Fuyuhiko Motoi,Takeshi Naitoh,Yu Katayose,Shinichi Egawa,Michiaki Unno,Toru Furukawa +9 more
TL;DR: In this article, the authors examined in vitro phenotypes of cells of pancreatic ductal lineage, HPDE, PK-8, PCI-35 and MIA PaCa-2, with exogenous expression of either wild-type or mutated (R201H) GNAS.
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Feedback regulation of DUSP6 transcription responding to MAPK1 via ETS2 in human cells.
TL;DR: The results indicate that intron 1 of D USP6 plays a crucial role in transcriptional regulation of DUSP6 in a feedback loop manner responding to MAPK1 via ETS2 in human cells.