Kimi Araki

TL;DR: The MIN6 cell line will be especially useful to analyze the molecular mechanisms by which beta cells regulate insulin secretion in response to extracellular glucose concentrations, and a possible role of GT isoforms in glucose sensing by beta cells is discussed.

TL;DR: CBP +/- mice would be an excellent model for the study of the role of CBP in development and memory storage mechanisms, and studies with step-through-type passive avoidance tests and with fear conditioning test showed that mice were deficient in long-term memory (LTM).

TL;DR: It is found that cytoplasmic vacuoles induced in pancreatic acinar cells by experimental pancreatitis were autophagic in origin, as demonstrated by microtubule-associated protein 1 light chain 3 expression and electron microscopy experiments, and trypsinogen activation was greatly reduced in the absence of autophagy.

TL;DR: Results demonstrate that the HBV genome integrated into the mouse chromosome acted as a template for viral gene expression, allowing viral replication, and should be useful for detailed studies of the replication and expression of HBV and for pathological studies of hepatitis, including the development of hepatocellular carcinoma.

TL;DR: It is demonstrated that CBP plays an essential role in hematopoiesis and vasculo-angiogenesis and the analyses demonstrate that these defects were partially rescued by the addition of VEGF to this culture.