Eugen Faist

TL;DR: High mobility group-1 (HMG-1) protein was found to be released by cultured macrophages more than 8 hours after stimulation with endotoxin, TNF, or IL-1, and showed increased serum levels after endotoxin exposure, suggesting that this protein warrants investigation as a therapeutic target.

TL;DR: Earlier pulmonary and cardiovascular support beginning at the scene of the accident, and prevention and better treatment of head injury, respiratory failure, and sepsis are critical factors for increasing survival after injury.

TL;DR: Recommendation to strive to prevent MODS and SIRS is described and it is indicated that certain problems are decreasing in frequency, such as renal failure and ARDS after trauma, stress gastrointestinal bleeding, and abdominal abscesses, and these should improve outcome.

TL;DR: It is believed that only a combination of drugs can effectively control the posttraumatic dyshomeostasis of the various cell systems and that immune modulatory interventions should be started as early as possible after trauma in a preventive fashion to protect against organ tissue destruction.

TL;DR: A candidate framework for such a system, based on the infection, the host response, and the extent of organ dysfunction (the IRO system) is described.