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Eugen Faist
Researcher at Ludwig Maximilian University of Munich
Publications - 117
Citations - 9140
Eugen Faist is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Sepsis & Cytokine. The author has an hindex of 36, co-authored 117 publications receiving 8793 citations.
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Journal ArticleDOI
HMG-1 as a Late Mediator of Endotoxin Lethality in Mice
Haichao Wang,Ona Bloom,Minghuang Zhang,Jaideep M. Vishnubhakat,Michael Ombrellino,Jiantu Che,Asia Frazier,Huan Yang,Svetlana Ivanova,Lyudmila V. Borovikova,Kirk R. Manogue,Eugen Faist,Edward Abraham,Jan Andersson,Ulf Andersson,Patricia E. Molina,Naji N. Abumrad,Andrew E. Sama,Kevin J. Tracey +18 more
TL;DR: High mobility group-1 (HMG-1) protein was found to be released by cultured macrophages more than 8 hours after stimulation with endotoxin, TNF, or IL-1, and showed increased serum levels after endotoxin exposure, suggesting that this protein warrants investigation as a therapeutic target.
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Multiple organ failure in polytrauma patients
TL;DR: Earlier pulmonary and cardiovascular support beginning at the scene of the accident, and prevention and better treatment of head injury, respiratory failure, and sepsis are critical factors for increasing survival after injury.
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Systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), multiple organ failure (MOF): are we winning the battle?
TL;DR: Recommendation to strive to prevent MODS and SIRS is described and it is indicated that certain problems are decreasing in frequency, such as renal failure and ARDS after trauma, stress gastrointestinal bleeding, and abdominal abscesses, and these should improve outcome.
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Update on the Mechanisms of Immune Suppression of Injury and Immune Modulation
TL;DR: It is believed that only a combination of drugs can effectively control the posttraumatic dyshomeostasis of the various cell systems and that immune modulatory interventions should be started as early as possible after trauma in a preventive fashion to protect against organ tissue destruction.
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Measures, markers, and mediators: toward a staging system for clinical sepsis. A report of the Fifth Toronto Sepsis Roundtable, Toronto, Ontario, Canada, October 25-26, 2000.
John C. Marshall,Jean Louis Vincent,Mitchell P. Fink,Deborah J. Cook,Gordon D. Rubenfeld,Debra Foster,Charles J. Fisher,Eugen Faist,Konrad Reinhart +8 more
TL;DR: A candidate framework for such a system, based on the infection, the host response, and the extent of organ dysfunction (the IRO system) is described.