John C. Reid

TL;DR: A Staphylococcus aureus antisense knockdown strategy is adapted to genetically identify the cell division Z ring components—FtsA, FtsZ, and FtsW—as β-lactam susceptibility determinants of methicillin-resistant S. aureUS to support a target-based approach to develop synergistic drug combinations to combat MRSA with improved efficacy and reduced potential for drug resistance.

TL;DR: A series of novel, highly potent NNRTIs that possess broad spectrum antiviral activity and good pharmacokinetic profiles are designed and synthesized to address a critical issue with the emergence of clinical resistance.

TL;DR: It is demonstrated that PC190723 negatively modulates Staphylococcus aureus FtsZ polymerization cooperativity as reflected in polymerization at lower concentrations without a defined critical concentration.

TL;DR: These structures provide a means for structurally guided design of novel RNase H inhibitors, and one of the naphthyridinone-based compounds was found to bind at a second site close to the polymerase active site and non-nucleoside/nucleotide inhibitor sites in a metal-independent manner.

TL;DR: The x-ray structure of the unactivated kinase domain of insulin-like growth factor-1 receptor (IGFRK-0P) is reported here at 2.7 Å resolution, suggesting that the juxtamembrane region of one molecule could come into close proximity to the active site of the other.