E
Eva Pagáčová
Researcher at Academy of Sciences of the Czech Republic
Publications - 13
Citations - 280
Eva Pagáčová is an academic researcher from Academy of Sciences of the Czech Republic. The author has contributed to research in topics: DNA repair & DNA damage. The author has an hindex of 9, co-authored 12 publications receiving 198 citations.
Papers
More filters
Journal ArticleDOI
Effect of gadolinium-based nanoparticles on nuclear DNA damage and repair in glioblastoma tumor cells
Lenka Štefančíková,Sandrine Lacombe,Daniela Salado,Erika Porcel,Eva Pagáčová,Olivier Tillement,François Lux,Daniel Depeš,Stanislav Kozubek,Martin Falk +9 more
TL;DR: The results suggest that the radiosensitization mediated by GdBNs is a cytoplasmic event that is independent of the nuclear DNA breakage, a phenomenon commonly accepted as the explanation of biological radiation effects.
Journal ArticleDOI
Two New Faces of Amifostine: Protector from DNA Damage in Normal Cells and Inhibitor of DNA Repair in Cancer Cells
Michal Hofer,Martin Falk,Denisa Komůrková,Iva Falková,Alena Bačíková,Bořivoj Klejdus,Eva Pagáčová,Lenka Štefančíková,Lenka Weiterová,Karel J. Angelis,Stanislav Kozubek,Ladislav Dušek,Štefan Galbavý +12 more
TL;DR: It is revealed by comet assay and currently the most sensitive method of DNA double strand break quantification that amifostine treatment supports DSB repair in γ-irradiated normal NHDF fibroblasts but alters it in MCF7 carcinoma cells.
Journal ArticleDOI
Challenges and Contradictions of Metal Nano-Particle Applications for Radio-Sensitivity Enhancement in Cancer Therapy
Eva Pagáčová,Lenka Štefančíková,Franz Schmidt-Kaler,Georg Hildenbrand,Tomas Vicar,Daniel Depeš,Jin-Ho Lee,Felix Bestvater,Sandrine Lacombe,Erika Porcel,Stéphane Roux,Frederik Wenz,Olga Kopečná,Iva Falková,Michael Hausmann,Martin Falk +15 more
TL;DR: The data show that different nanoparticles may or may not enhance radiation damage to DNA, so multi-parameter effects have to be considered to better interpret the radiosensitization.
Journal ArticleDOI
Post‐Translational Modifications of Histones in Human Sperm
Jana Krejčí,Lenka Stixová,Eva Pagáčová,Soňa Legartová,Stanislav Kozubek,Gabriela Lochmanová,Zbyněk Zdráhal,Petra Sehnalová,Siarhei A. Dabravolski,Jan Hejátko,Eva Bártová +10 more
TL;DR: Data indicate that particular post‐translational modifications of histones are uniquely distributed in human sperm, and this distribution varies among individuals and among the sperm of a single individual.
Journal ArticleDOI
Recruitment of 53BP1 Proteins for DNA Repair and Persistence of Repair Clusters Differ for Cell Types as Detected by Single Molecule Localization Microscopy.
Elizaveta Bobkova,Daniel Depeš,Jin-Ho Lee,Lucie Jezkova,Iva Falková,Eva Pagáčová,Olga Kopečná,M. G. Zadneprianetc,Alena Bačíková,E. A. Kulikova,E. V. Smirnova,Tatiana Bulanova,Alla Boreyko,Evgeny Krasavin,Frederik Wenz,Felix Bestvater,Georg Hildenbrand,Michael Hausmann,Martin Falk +18 more
TL;DR: SMLM is a highly appropriate method for investigations of spatiotemporal protein organization in cell nuclei and how it influences the cell decision for a particular repair pathway at a given DSB site is demonstrated.