Evangelia Komisopoulou

TL;DR: The recent discovery of mutations in metabolic enzymes has rekindled interest in harnessing the altered metabolism of cancer cells for cancer therapy, and isocitrate dehydrogenase 1 (IDH1), which is mutated in multiple human cancers, is examined.

TL;DR: An essential role for sterol regulatory element–binding proteins (SREBPs) in the acquisition of effector-cell metabolism is demonstrated and insights into the molecular signals that underlie the metabolic reprogramming of CD8+ T cells during the transition from quiescence to activation are provided.

TL;DR: In cultured cells, type I interferon and its downstream signaling cascade inhibited the antimicrobial response induced by type II interferons, providing a potential explanation for why robust disease rather than protection is seen in some cases of infection.

TL;DR: The findings show how a viral protein exploits host cell machinery to reprogram cellular metabolism and promote optimal progeny virion generation.

TL;DR: This article identified 13 miRNAs that were differentially expressed in the lesions of subjects with progressive lepromatous versus the self-limited tuberculoid (T-lep) disease and showed that the ability of leprae to upregulate hsa-mir-21 targets multiple genes associated with the immunologically localized disease form, providing an effective mechanism to escape from the vitamin D-dependent antimicrobial pathway.