E
Eve Lapouble
Researcher at PSL Research University
Publications - 3
Citations - 359
Eve Lapouble is an academic researcher from PSL Research University. The author has contributed to research in topics: Anaplastic lymphoma kinase & Epigenomics. The author has an hindex of 2, co-authored 3 publications receiving 266 citations. Previous affiliations of Eve Lapouble include Uppsala University.
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Journal ArticleDOI
DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma
Nathan C. Sheffield,Gaëlle Pierron,Johanna Klughammer,Paul Datlinger,Andreas Schönegger,Michael Schuster,Johanna Hadler,Didier Surdez,Delphine Guillemot,Eve Lapouble,Paul Fréneaux,Jacqueline Champigneulle,Raymonde Bouvier,Diana Walder,I.M. Ambros,Caroline Hutter,Caroline Hutter,Eva Sorz,Ana Teresa Amaral,Enrique de Álava,Katharina Schallmoser,Dirk Strunk,Beate Rinner,Bernadette Liegl-Atzwanger,Berthold Huppertz,Andreas Leithner,Gonzague de Pinieux,Philippe Terrier,V. Laurence,Jean Michon,Ruth Ladenstein,Ruth Ladenstein,Wolfgang Holter,Wolfgang Holter,Reinhard Windhager,Uta Dirksen,Peter F. Ambros,Olivier Delattre,Heinrich Kovar,Christoph Bock,Eleni M. Tomazou +40 more
TL;DR: This study performed genome-scale DNA methylation sequencing for a large cohort of Ewing sarcoma tumors and observed consistent DNA hypomethylation at enhancers regulated by the disease-defining EWS-FLI1 fusion protein, thus establishing epigenomic enhancer reprogramming as a ubiquitous and characteristic feature of Ewings Sarcoma.
Journal ArticleDOI
Emergence of New ALK Mutations at Relapse of Neuroblastoma
Gudrun Schleiermacher,Niloufar Javanmardi,Virginie Bernard,Quentin Leroy,Julie Cappo,Thomas Rio Frio,Gaëlle Pierron,Eve Lapouble,Valérie Combaret,Franki Speleman,Bram De Wilde,Anna Djos,Ingrid Øra,Fredrik Hedborg,Catarina Träger,Britt-Marie Holmqvist,Jonas Abrahamsson,Michel Peuchmaur,Jean Michon,Isabelle Janoueix-Lerosey,Per Kogner,Olivier Delattre,Tommy Martinsson +22 more
TL;DR: In neuroblastoma, subclonal ALK mutations can be present at diagnosis with subsequent clonal expansion at relapse, highlighting the potential of deep sequencing for detection of sub clonal mutations with a sensitivity 100-fold that of Sanger sequencing and the importance of serial samplings for therapeutic decisions.
Journal ArticleDOI
Molecular diagnosis of retinoblastoma by circulating tumor DNA analysis.
Irene Jiménez,Éléonore Frouin,Mathieu Chicard,Catherine Dehainault,Jessica Le Gall,Camille Benoist,Arnaud Gauthier,Eve Lapouble,Claude Houdayer,François Radvanyi,Virginie Bernard,Hervé Brisse,Marion Gauthier-Villars,Dominique Stoppa-Lyonnet,Sylvain Baulande,Nathalie Cassoux,Livia Lumbroso,Alexandre Matet,Isabelle Aerts,Victor Renault,François Doz,Lisa Golmard,Olivier Delattre,G Schleiermacher +23 more
TL;DR: In this article, the detection of circulating tumor DNA (ctDNA), a fraction of total cell-free DNA (cfDNA), might be of special interest in retinoblastoma patients by molecular analysis of RB1 gene.