C
Catarina Träger
Researcher at Karolinska Institutet
Publications - 12
Citations - 626
Catarina Träger is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Population & Odds ratio. The author has an hindex of 9, co-authored 12 publications receiving 540 citations. Previous affiliations of Catarina Träger include Karolinska University Hospital & Linköping University.
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Journal ArticleDOI
High-risk neuroblastoma tumors with 11q-deletion display a poor prognostic, chromosome instability phenotype with later onset
Helena Carén,Hanna Kryh,Maria Nethander,Rose-Marie Sjöberg,Catarina Träger,Staffan Nilsson,Jonas Abrahamsson,Per Kogner,Tommy Martinsson +8 more
TL;DR: In the groups with segmental aberrations without MNA or 11q deletion, the tumors with 17q gain have worse prognosis than those with segmentals without 17Q gain, which have a favorable outcome, and this study stresses that genome-wide microarray analyses should be included in clinical management.
Journal ArticleDOI
Emergence of New ALK Mutations at Relapse of Neuroblastoma
Gudrun Schleiermacher,Niloufar Javanmardi,Virginie Bernard,Quentin Leroy,Julie Cappo,Thomas Rio Frio,Gaëlle Pierron,Eve Lapouble,Valérie Combaret,Franki Speleman,Bram De Wilde,Anna Djos,Ingrid Øra,Fredrik Hedborg,Catarina Träger,Britt-Marie Holmqvist,Jonas Abrahamsson,Michel Peuchmaur,Jean Michon,Isabelle Janoueix-Lerosey,Per Kogner,Olivier Delattre,Tommy Martinsson +22 more
TL;DR: In neuroblastoma, subclonal ALK mutations can be present at diagnosis with subsequent clonal expansion at relapse, highlighting the potential of deep sequencing for detection of sub clonal mutations with a sensitivity 100-fold that of Sanger sequencing and the importance of serial samplings for therapeutic decisions.
Journal ArticleDOI
Incidence of childhood central nervous system tumors in the Nordic countries
Lisbeth Samsø Schmidt,Kjeld Schmiegelow,Kjeld Schmiegelow,Päivi M. Lähteenmäki,Catarina Träger,Tore Stokland,Katrine Grell,Göran Gustafson,Astrid Sehested,Ole Raashou-Nielsen,Christoffer Johansen,Joachim Schüz +11 more
TL;DR: The incidence rates of childhood central nervous system tumors in the Nordic countries remain among the highest in the world and increasing incidence rates would be a public health concern, as they might indicate increased exposure to environmental risk factors.
Journal ArticleDOI
Fetal Growth, Preterm Birth, Neonatal Stress and Risk for CNS Tumors in Children: A Nordic Population- and Register-Based Case-Control Study
Lisbeth Samsø Schmidt,Joachim Schüz,Päivi M. Lähteenmäki,Catarina Träger,Tore Stokland,Göran Gustafson,Lisa Lyngsie Hjalgrim,Astrid Sehested,Christoffer Johansen,Kjeld Schmiegelow +9 more
TL;DR: A U-shaped relation between risk for CNS tumors and birthweight and the findings provide insight into the natural history of childhood CNS tumors indicating an early onset or, alternatively, potentially harmful exposures in the neonatal period that might be preventable.
Journal ArticleDOI
MYCN-amplified neuroblastoma maintains an aggressive and undifferentiated phenotype by deregulation of estrogen and NGF signaling.
J Dzieran,Aida Rodriguez Garcia,Ulrica K. Westermark,Aine Brigette Henley,Elena Eyre Sánchez,Catarina Träger,Henrik J. Johansson,Henrik J. Johansson,Janne Lehtiö,Janne Lehtiö,Marie Arsenian-Henriksson +10 more
TL;DR: It is demonstrated that interference with miR-18a or overexpression of ERα is sufficient to induce NGF signaling and to modulate both basal and NGF-induced neuronal differentiation in MYCN-amplified NB cells, suggesting that MYCN targets ERα and thereby NGF signalling to maintain an undifferentiated and aggressive phenotype.