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Evelyn Dixit
Researcher at Boston Children's Hospital
Publications - 6
Citations - 2512
Evelyn Dixit is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Innate immune system & Signal transducing adaptor protein. The author has an hindex of 6, co-authored 6 publications receiving 2311 citations. Previous affiliations of Evelyn Dixit include Austrian Academy of Sciences.
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Journal ArticleDOI
An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome
Tilmann Bürckstümmer,Christoph Baumann,Stephan Blüml,Stephan Blüml,Evelyn Dixit,Gerhard Dürnberger,Hannah Jahn,Melanie Planyavsky,Martin Bilban,Jacques Colinge,Keiryn L. Bennett,Giulio Superti-Furga +11 more
TL;DR: A systematic proteomics screen for proteins that associate with DNA, 'crossed' to a screen for transcripts induced by interferon-β identified AIM2 as a candidate cytoplasmic DNA sensor for the inflammasome, which showed specificity for double-stranded DNA.
Journal ArticleDOI
Peroxisomes are signaling platforms for antiviral innate immunity
Evelyn Dixit,Steeve Boulant,Yijing Zhang,Amy S. Lee,Charlotte Odendall,Bennett O.V. Shum,Nir Hacohen,Zhijian J. Chen,Sean P. J. Whelan,Marc Fransen,Max L. Nibert,Giulio Superti-Furga,Jonathan C. Kagan +12 more
TL;DR: It is reported that the RIG-I-like receptor (RLR) adaptor protein MAVS is located on peroxisomes and mitochondria and it is found thatperoxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state.
Journal ArticleDOI
Diverse intracellular pathogens activate type III interferon expression from peroxisomes
Charlotte Odendall,Evelyn Dixit,Fabrizia Stavru,Hélène Bierne,Kate M Franz,Ann Fiegen Durbin,Steeve Boulant,Lee Gehrke,Pascale Cossart,Jonathan C. Kagan +9 more
TL;DR: It is revealed that the process of intestinal epithelial cell differentiation upregulates peroxisome biogenesis and promotes robust type III interferon responses in human cells, highlighting the importance of different intracellular organelles in specific innate immune responses.
Diverse intracellular pathogens activate type III interferon expression from peroxisomes
Charlotte Odendall,Evelyn Dixit,Fabrizia Stavru,Hélène Bierne,Kate M Franz,Ann Fiegen Durbin,Steeve Boulant,Lee Gehrke,Pascale Cossart,Jonathan C. Kagan +9 more
TL;DR: The authors found that RIG-I like receptors (RLRs) induce type III interferon expression in a variety of human cell types, and identified factors that differentially regulate expression of type I and type 3 interferons.
Book ChapterDOI
Intracellular pathogen detection by RIG-I-like receptors.
Evelyn Dixit,Jonathan C. Kagan +1 more
TL;DR: This review focuses on the molecular and cell biological requirements for RLR signal transduction.