F. Eun-Hyung Lee

TL;DR: The molecular mechanisms behind the heterogeneity of airway inflammation in asthmatic patients are presented, which have shifted existing paradigms in the approach to asthma to tailor novel therapies.

TL;DR: A distinct differentiation fate of autoreactive naive B cells into PC precursors with hyper‐responsiveness to innate stimuli is defined as well as establishes prominence of extra‐follicular B cell activation in SLE, and identifies therapeutic targets.

TL;DR: Overall, these findings strongly suggest a pathogenic role for immune activation in subsets of patients with COVID-19, and provide further evidence that targeted immunomodulatory therapy may be beneficial in specific patient subpopulations and can be informed by careful immune profiling.

TL;DR: A platform for rapid antibody discovery enabled the isolation of hundreds of human monoclonal antibodies against SARS-CoV-2 and the prioritization of potent antibody candidates for clinical trials in patients with COVID-19, and demonstrates the speed and robustness of advanced antibody discovery platforms.

TL;DR: Deep sequencing, proteomic profiling of autoantibodies and single-cell analysis demonstrated highly diversified ASCs punctuated by clones expressing the variable heavy-chain region VH4-34 that produced dominant serum autoantIBodies, shed light on the pathogenesis of SLE and explain the benefit of agents that target B cells and should facilitate the design of future therapies.