J
Jaime Darce
Researcher at Cell Signaling Technology
Publications - 4
Citations - 813
Jaime Darce is an academic researcher from Cell Signaling Technology. The author has contributed to research in topics: Antigen & Autoantibody. The author has an hindex of 3, co-authored 4 publications receiving 579 citations.
Papers
More filters
Journal ArticleDOI
Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus
Christopher M. Tipton,Christopher F. Fucile,Jaime Darce,Asiya Seema Chida,Travis Ichikawa,Ivan V. Gregoretti,Sandra M Schieferl,Jennifer Hom,Scott A. Jenks,Ron J. Feldman,Ramit Mehr,Chungwen Wei,F. Eun-Hyung Lee,Wan Cheung Cheung,Alexander F. Rosenberg,Iñaki Sanz +15 more
TL;DR: Deep sequencing, proteomic profiling of autoantibodies and single-cell analysis demonstrated highly diversified ASCs punctuated by clones expressing the variable heavy-chain region VH4-34 that produced dominant serum autoantIBodies, shed light on the pathogenesis of SLE and explain the benefit of agents that target B cells and should facilitate the design of future therapies.
Journal ArticleDOI
Long-Lived Plasma Cells Are Contained within the CD19(-)CD38(hi)CD138(+) Subset in Human Bone Marrow.
Jessica L. Halliley,Jessica L. Halliley,Christopher M. Tipton,Jane L. Liesveld,Alexander F. Rosenberg,Jaime Darce,Ivan V. Gregoretti,Lana Popova,Denise A. Kaminiski,Christopher F. Fucile,Igor Albizua,Shuya Kyu,Kuang-Yueh Chiang,Kyle T. Bradley,Richard Burack,Mark K. Slifka,Erika Hammarlund,Hao Wu,Liping Zhao,Edward E. Walsh,Ann R. Falsey,Troy D. Randall,Wan Cheung Cheung,Iñaki Sanz,F. Eun-Hyung Lee +24 more
TL;DR: Human LLPCs are defined and a mechanism for the life-long maintenance of anti-viral antibodies in the serum is provided and probably represents the B cell response's "historical record" of antigenic exposure.
Journal ArticleDOI
Influenza vaccine–induced human bone marrow plasma cells decline within a year after vaccination
Carl W. Davis,Katherine J. L. Jackson,Megan McCausland,Jaime Darce,Cathy Y. Chang,Susanne L. Linderman,Chakravarthy Chennareddy,Rebecca Gerkin,Shantoria J. Brown,Jens Wrammert,Aneesh K. Mehta,Wan Cheung Cheung,Scott D. Boyd,Edmund K. Waller,Rafi Ahmed +14 more
TL;DR: The results suggest that most BMPCs generated by influenza vaccination in adults are short-lived, and designing strategies to enhance their persistence will be a key challenge for the next generation of influenza vaccines.
Proceedings ArticleDOI
Abstract 4595: Development and validation of a novel EGF receptor-neutralizing monoclonal antibody
Krystyna Zuberek Hincman,Christopher A. Manning,Michael R. Nelson,Michael Lewis,Roy Scialdone,Jaime Darce,Stephen R. Lutz,Evans Burford,Herbert Haack,Matthew Ren Silver +9 more
TL;DR: Compared to other Research Use Only (RUO) neutralizing antibodies on the market, D1D4J shows superior performance and is a useful research tool in the EGFR signaling space.