Chungwen Wei

TL;DR: A distinct differentiation fate of autoreactive naive B cells into PC precursors with hyper‐responsiveness to innate stimuli is defined as well as establishes prominence of extra‐follicular B cell activation in SLE, and identifies therapeutic targets.

TL;DR: A new population of memory B cells containing isotype-switched (IgG and IgA) and IgM-only cells and lacking expression of CD27 and IgD is described, enhancing the understanding of the B cell diversification pathways and providing mechanistic insight into the immunopathogenesis of SLE.

TL;DR: Deep sequencing, proteomic profiling of autoantibodies and single-cell analysis demonstrated highly diversified ASCs punctuated by clones expressing the variable heavy-chain region VH4-34 that produced dominant serum autoantIBodies, shed light on the pathogenesis of SLE and explain the benefit of agents that target B cells and should facilitate the design of future therapies.

TL;DR: Information emerging regarding the heterogeneity of human memory B cells is reviewed to improve ability to target specific B cell subsets either in vaccine responses or in autoimmune diseases and organ rejection among other pathological conditions where B cells play central pathogenic roles.

TL;DR: This study delineates refined subsets of transitional B cells, including a late transitional B cell subset with a phenotype intermediate between T2 and mature naive, which appears temporally following the T1 and T2 populations in the peripheral compartment after rituximab-induced B cell reconstitution.