Fabrice Agou

TL;DR: A flat cellular variant of HTLV-1 Tax-transformed rat fibroblasts, 5R, which is unresponsive to all tested NF-κB activating stimuli is characterized, and its genetic complementation is reported.

TL;DR: It is suggested that LUBAC regulates NF-κB–dependent IL-1β responses differently in different cell types, consistent with the unique association of autoinflammation and immunodeficiency in patients from two kindreds.

TL;DR: It is demonstrated that together they form a bipartite high‐affinity K63‐specific ubiquitin‐binding domain, which suggests that the main function of the C‐terminal half of NEMO is to specifically bind K 63‐linked poly‐ubiquitin chains.

TL;DR: In vivo cross-linking experiments indicate that native N EMO in association with IKK is in equilibrium between a dimeric and a trimeric form, suggesting that the association of NEMO with Ikk or with Hsp70 prevents incorrect interdomain pairing reactions that could lead to aggregation or to an non-native oligomeric state of rNEMO.

TL;DR: Functional complementation assays and in vivo pull-down experiments further show that ZF residues involved in ubiquitin binding are functionally important and required for NF-κB signaling in response to tumor necrosis factor-α.