Fanny Matheis

TL;DR: It is found that the gut microbiome modulates gut-extrinsic sympathetic neurons: microbiota depletion leads to increased expression of the neuronal transcription factor cFos, and colonization of germ-free mice with bacteria that produce short-chain fatty acids suppresses cFOS expression in the gut sympathetic ganglia.

TL;DR: The results identify a mechanism of neuronal death post-infection and point to a role for tissue-resident MMs in limiting neuronal damage.

TL;DR: It is shown that pTreg cell deficiency impedes the establishment of a subset of intestinal bacteria due to heightened immune responses, with significant effects on host metabolites and fitness.

TL;DR: It is found that intrinsic enteric-associated neurons (iEANs) in mice are functionally adapted to the intestinal segment they occupy; ileal and colonic neurons are more responsive to microbial colonization than duodenal neurons.

TL;DR: Recent advances in the understanding of the origin, phenotype and function of macrophages residing in the different layers of the intestine during homeostasis and under pathological conditions are discussed.