D
Daniel Mucida
Researcher at Rockefeller University
Publications - 118
Citations - 13918
Daniel Mucida is an academic researcher from Rockefeller University. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 45, co-authored 97 publications receiving 11196 citations. Previous affiliations of Daniel Mucida include Howard Hughes Medical Institute & La Jolla Institute for Allergy and Immunology.
Papers
More filters
Journal ArticleDOI
Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid.
Daniel Mucida,Yunji Park,Gisen Kim,Olga Turovskaya,Iain Scott,Mitchell Kronenberg,Hilde Cheroutre +6 more
TL;DR: The vitamin A metabolite retinoic acid is identified as a key regulator of TGF-β–dependent immune responses, capable of inhibiting the IL-6–driven induction of proinflammatory TH17 cells and promoting anti-inflammatory Treg cell differentiation, indicating that a common metabolite can regulate the balance between pro- and anti- inflammatory immunity.
Journal ArticleDOI
IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer
Sergei I. Grivennikov,Eliad Karin,Janoš Terzić,Janoš Terzić,Daniel Mucida,Guann-Yi Yu,Sivakumar Vallabhapurapu,Jürgen Scheller,Stefan Rose-John,Hilde Cheroutre,Lars Eckmann,Michael Karin +11 more
TL;DR: It is demonstrated that IL-6 is a critical tumor promoter during early CAC tumorigenesis and the NF-kappaB-IL-6-Stat3 cascade is an important regulator of the proliferation and survival of tumor-initiating IECs.
Journal ArticleDOI
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth.
Sergei I. Grivennikov,Kepeng Wang,Daniel Mucida,C. Andrew Stewart,Bernd Schnabl,Dominik Jauch,Koji Taniguchi,Guann-Yi Yu,Christoph H. Österreicher,Kenneth E. Hung,Christian Datz,Ying Feng,Eric R. Fearon,Mohamed Oukka,Lino Tessarollo,Vincenzo Coppola,Felix Yarovinsky,Hilde Cheroutre,Lars Eckmann,Giorgio Trinchieri,Michael Karin +20 more
TL;DR: It is proposed that barrier deterioration induced by colorectal-cancer-initiating genetic lesions results in adenoma invasion by microbial products that trigger tumour-elicited inflammation, which in turn drives tumour growth.
Journal ArticleDOI
A defined commensal consortium elicits CD8 T cells and anti-cancer immunity
Takeshi Tanoue,Satoru Morita,Damian R. Plichta,Ashwin N. Skelly,Wataru Suda,Wataru Suda,Yuki Sugiura,Seiko Narushima,Hera Vlamakis,Iori Motoo,Kayoko Sugita,Atsushi Shiota,Kozue Takeshita,Keiko Yasuma-Mitobe,Dieter Riethmacher,Tsuneyasu Kaisho,Jason M. Norman,Daniel Mucida,Makoto Suematsu,Tomonori Yaguchi,Vanni Bucci,Takashi Inoue,Yutaka Kawakami,Bernat Olle,Bruce L. Roberts,Masahira Hattori,Masahira Hattori,Ramnik J. Xavier,Ramnik J. Xavier,Koji Atarashi,Kenya Honda +30 more
TL;DR: A consortium of 11 bacterial strains from the healthy human gut microbiota can strongly induce interferon-γ-producing CD8 T cells in the intestine, and enhance both resistance to bacterial infection and the therapeutic efficacy of immune checkpoint inhibitors in syngeneic tumour models.
Journal ArticleDOI
The light and dark sides of intestinal intraepithelial lymphocytes
TL;DR: This Review addresses how the unique development and functions of intestinal IELs allow them to achieve a balance of protective immunity with an ability to safeguard the integrity of the epithelial barrier.