Faye S. Silverstein

TL;DR: The results suggest that this neurotoxic mechanism is extremely active in the immature brain and implicated excessiveN-methyl-d-aspartate receptor activation in the pathogenesis of hypopoxic-ischemic and hypoglycemic injury.

TL;DR: In this paper, a trial of two targeted temperature interventions at 38 children's hospitals involving children who remained unconscious after out-of-hospital cardiac arrest was conducted, and the primary efficacy outcome, survival at 12 months after cardiac arrest with a Vineland Adaptive Behavior Scales, second edition (VABS-II), score of 70 or higher (on a scale from 20 to 160, with higher scores indicating better function), was evaluated among patients with at least 70 before cardiac arrest.

TL;DR: The results suggest that IL-1 beta and TNF-alpha may play important roles in the response of the developing brain to acute hypoxic-ischemic injury.

TL;DR: To examine this hypothesis in neonatal brain, MK-80I , a novel noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, was tested using an in vivo experimental model of hypoxic-ischemic forebrain injury.

TL;DR: In this article, a large contemporary profile of consecutively enrolled newborns with seizures treated at centers that use continuous video-electroencephalogram (cEEG) per the guidelines of the American Clinical Neurophysiology Society, about one-half had high seizure burden, received ≥2 antiseizure medications, and/or died or had abnormal examination at discharge.