L
Leonardo Elia
Researcher at University of Brescia
Publications - 36
Citations - 4344
Leonardo Elia is an academic researcher from University of Brescia. The author has contributed to research in topics: Vascular smooth muscle & microRNA. The author has an hindex of 21, co-authored 31 publications receiving 3789 citations. Previous affiliations of Leonardo Elia include Merck & Co. & National Research Council.
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Journal ArticleDOI
MicroRNA-133 controls cardiac hypertrophy
Alessandra Carè,Daniele Catalucci,Federica Felicetti,Désirée Bonci,Antonio Addario,Paolo Gallo,Marie Louise Bang,Patrizia Segnalini,Yusu Gu,Nancy D. Dalton,Leonardo Elia,Michael V.G. Latronico,Morten A. Høydal,Camillo Autore,Matteo Antonio Russo,Gerald W. Dorn,Øyvind Ellingsen,Pilar Ruiz-Lozano,Kirk L. Peterson,Carlo M. Croce,Cesare Peschle,Gianluigi Condorelli +21 more
TL;DR: The data show thatmiR-133, and possibly miR-1, are key regulators of cardiac hypertrophy, suggesting their therapeutic application in heart disease.
Journal ArticleDOI
The knockout of miR-143 and -145 alters smooth muscle cell maintenance and vascular homeostasis in mice: correlates with human disease
Leonardo Elia,Manuela Quintavalle,Jianlin Zhang,Riccardo Contu,Luca Cossu,Michael V.G. Latronico,Kirk L. Peterson,Ciro Indolfi,Daniele Catalucci,Ju Chen,Sara A. Courtneidge,Gianluigi Condorelli +11 more
TL;DR: The results show that the miR-143/145 gene cluster has a critical role during SMC differentiation and strongly suggest its involvement in the reversion of the VSMC differentiation phenotype that occurs during vascular disease.
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Reciprocal Regulation of MicroRNA-1 and Insulin-Like Growth Factor-1 Signal Transduction Cascade in Cardiac and Skeletal Muscle in Physiological and Pathological Conditions
Leonardo Elia,Riccardo Contu,Manuela Quintavalle,Francesca Varrone,Cristina Chimenti,Matteo Antonio Russo,Vincenzo Cimino,Laura De Marinis,Andrea Frustaci,Daniele Catalucci,Gianluigi Condorelli +10 more
TL;DR: A critical role is revealed in mediating the effects of the IGF-1 pathway and a feedback loop between miR-1 expression and theIGF-1 signal transduction cascade is demonstrated.
Journal ArticleDOI
MicroRNA control of podosome formation in vascular smooth muscle cells in vivo and in vitro
Manuela Quintavalle,Leonardo Elia,Leonardo Elia,Gianluigi Condorelli,Gianluigi Condorelli,Sara A. Courtneidge +5 more
TL;DR: PDGF enhances podosome formation and cell migration by regulating expression of the microRNAs miR-143 and -145, which target PDGF-R, PKC-ε, and fascin.
Journal ArticleDOI
Ferritin, cellular iron storage and regulation
TL;DR: Findings on the connections between iron storage, cellular iron regulation and ferritin iron recycling that have been explored in unicellular organisms and in animals are discussed.