XI. STRATEGIES FOR IMPROVING DIABETES CARE D iabetes is a chronic illness that requires continuing medical care and patient self-management education to prevent acute complications and to reduce the risk of long-term complications. Diabetes care is complex and requires that many issues, beyond glycemic control, be addressed. A large body of evidence exists that supports a range of interventions to improve diabetes outcomes. These standards of care are intended to provide clinicians, patients, researchers, payors, and other interested individuals with the components of diabetes care, treatment goals, and tools to evaluate the quality of care. While individual preferences, comorbidities, and other patient factors may require modification of goals, targets that are desirable for most patients with diabetes are provided. These standards are not intended to preclude more extensive evaluation and management of the patient by other specialists as needed. For more detailed information, refer to Bode (Ed.): Medical Management of Type 1 Diabetes (1), Burant (Ed): Medical Management of Type 2 Diabetes (2), and Klingensmith (Ed): Intensive Diabetes Management (3). The recommendations included are diagnostic and therapeutic actions that are known or believed to favorably affect health outcomes of patients with diabetes. A grading system (Table 1), developed by the American Diabetes Association (ADA) and modeled after existing methods, was utilized to clarify and codify the evidence that forms the basis for the recommendations. The level of evidence that supports each recommendation is listed after each recommendation using the letters A, B, C, or E.

Standards of Medical Care in Diabetes

Topological photonics is a rapidly emerging field of research in which geometrical and topological ideas are exploited to design and control the behavior of light. Drawing inspiration from the discovery of the quantum Hall effects and topological insulators in condensed matter, recent advances have shown how to engineer analogous effects also for photons, leading to remarkable phenomena such as the robust unidirectional propagation of light, which hold great promise for applications. Thanks to the flexibility and diversity of photonics systems, this field is also opening up new opportunities to realize exotic topological models and to probe and exploit topological effects in new ways. This article reviews experimental and theoretical developments in topological photonics across a wide range of experimental platforms, including photonic crystals, waveguides, metamaterials, cavities, optomechanics, silicon photonics, and circuit QED. A discussion of how changing the dimensionality and symmetries of photonics systems has allowed for the realization of different topological phases is offered, and progress in understanding the interplay of topology with non-Hermitian effects, such as dissipation, is reviewed. As an exciting perspective, topological photonics can be combined with optical nonlinearities, leading toward new collective phenomena and novel strongly correlated states of light, such as an analog of the fractional quantum Hall effect.

Topological Photonics

to be done in this area. Face recognition is a problem that scarcely clamoured for attention before the computer age but, having surfaced, has involved a wide range of techniques and has attracted the attention of some fine minds (David Mumford was a Fields Medallist in 1974). This singular application of mathematical modelling to a messy applied problem of obvious utility and importance but with no unique solution is a pretty one to share with students: perhaps, returning to the source of our opening quotation, we may invert Duncan's earlier observation, 'There is an art to find the mind's construction in the face!'.

Linear and nonlinear waves, by G. B. Whitham. Pp.636. £50. 1999. ISBN 0 471 35942 4 (Wiley).

日本物理学会誌及びJournal of the Physical Society of Japanの月刊について

The state-of-the-art models for medical image segmentation are variants of U-Net and fully convolutional networks (FCN). Despite their success, these models have two limitations: (1) their optimal depth is apriori unknown, requiring extensive architecture search or inefficient ensemble of models of varying depths; and (2) their skip connections impose an unnecessarily restrictive fusion scheme, forcing aggregation only at the same-scale feature maps of the encoder and decoder sub-networks. To overcome these two limitations, we propose UNet++, a new neural architecture for semantic and instance segmentation, by (1) alleviating the unknown network depth with an efficient ensemble of U-Nets of varying depths, which partially share an encoder and co-learn simultaneously using deep supervision; (2) redesigning skip connections to aggregate features of varying semantic scales at the decoder sub-networks, leading to a highly flexible feature fusion scheme; and (3) devising a pruning scheme to accelerate the inference speed of UNet++. We have evaluated UNet++ using six different medical image segmentation datasets, covering multiple imaging modalities such as computed tomography (CT), magnetic resonance imaging (MRI), and electron microscopy (EM), and demonstrating that (1) UNet++ consistently outperforms the baseline models for the task of semantic segmentation across different datasets and backbone architectures; (2) UNet++ enhances segmentation quality of varying-size objects—an improvement over the fixed-depth U-Net; (3) Mask RCNN++ (Mask R-CNN with UNet++ design) outperforms the original Mask R-CNN for the task of instance segmentation; and (4) pruned UNet++ models achieve significant speedup while showing only modest performance degradation. Our implementation and pre-trained models are available at https://github.com/MrGiovanni/UNetPlusPlus .

UNet++: Redesigning Skip Connections to Exploit Multiscale Features in Image Segmentation

The manipulation of acoustic wave propagation in fluids has numerous applications, including some in everyday life Acoustic technologies frequently develop in tandem with optics, using shared concepts such as waveguiding and metamedia It is thus noteworthy that an entirely novel class of electromagnetic waves, known as topological edge states, has recently been demonstrated These are inspired by the electronic edge states occurring in topological insulators, and possess a striking and technologically promising property: the ability to travel in a single direction along a surface without backscattering, regardless of the existence of defects or disorder Here, we develop an analogous theory of topological fluid acoustics, and propose a scheme for realizing topological edge states in an acoustic structure containing circulating fluids The phenomenon of disorder-free one-way sound propagation, which does not occur in ordinary acoustic devices, may have novel applications for acoustic isolators, modulators, and transducers

Topological Acoustics

Higher-order topological insulators1–5 are a family of recently predicted topological phases of matter that obey an extended topological bulk–boundary correspondence principle. For example, a two-dimensional (2D) second-order topological insulator does not exhibit gapless one-dimensional (1D) topological edge states, like a standard 2D topological insulator, but instead has topologically protected zero-dimensional (0D) corner states. The first prediction of a second-order topological insulator1, based on quantized quadrupole polarization, was demonstrated in classical mechanical6 and electromagnetic7,8 metamaterials. Here we experimentally realize a second-order topological insulator in an acoustic metamaterial, based on a ‘breathing’ kagome lattice9 that has zero quadrupole polarization but a non-trivial bulk topology characterized by quantized Wannier centres2,9,10. Unlike previous higher-order topological insulator realizations, the corner states depend not only on the bulk topology but also on the corner shape; we show experimentally that they exist at acute-angled corners of the kagome lattice, but not at obtuse-angled corners. This shape dependence allows corner states to act as topologically protected but reconfigurable local resonances. A second-order topological insulator in an acoustical metamaterial with a breathing kagome lattice, supporting one-dimensional edge states and zero-dimensional corner states is demonstrated.

/pdf/acoustic-higher-order-topological-insulator-on-a-kagome-2szcjantih.pdf

Acoustic higher-order topological insulator on a kagome lattice.

The ideal elastic limit is the upper bound to the stress and elastic strain a material can withstand. This intrinsic property has been widely studied for crystalline metals, both theoretically and experimentally. For metallic glasses, however, the ideal elastic limit remains poorly characterized and understood. Here we show that the elastic strain limit and the corresponding strength of submicron-sized metallic glass specimens are about twice as high as the already impressive elastic limit observed in bulk metallic glass samples, in line with model predictions of the ideal elastic limit of metallic glasses. We achieve this by employing an in situ transmission electron microscope tensile deformation technique. Furthermore, we propose an alternative mechanism for the apparent 'work hardening' behaviour observed in the tensile stress-strain curves.

http://li.mit.edu/Archive/Papers/12/Tian12ChengNC.pdf

Probing topological protection using a designer surface plasmon structure.

A photonic crystal can realize an analogue of a valley Hall insulator, promising more flexibility than in condensed-matter systems to explore these exotic topological states. Recently discovered1,2 valley photonic crystals (VPCs) mimic many of the unusual properties of two-dimensional (2D) gapped valleytronic materials3,4,5,6,7,8,9. Of the utmost interest to optical communications is their ability to support topologically protected chiral edge (kink) states3,4,5,6,7,8,9 at the internal domain wall between two VPCs with opposite valley-Chern indices. Here we experimentally demonstrate valley-polarized kink states with polarization multiplexing in VPCs, designed from a spin-compatible four-band model. When the valley pseudospin is conserved, we show that the kink states exhibit nearly perfect out-coupling efficiency into directional beams, through the intersection between the internal domain wall and the external edge separating the VPCs from ambient space. The out-coupling behaviour remains topologically protected even when we break the spin-like polarization degree of freedom (DOF), by introducing an effective spin–orbit coupling in one of the VPC domains. This also constitutes the first realization of spin–valley locking for topological valley transport.

/pdf/topologically-protected-refraction-of-robust-kink-states-in-5ghq4p1b1q.pdf

Topologically protected refraction of robust kink states in valley photonic crystals

We report the first experimental realization of a three-dimensional thermal cloak shielding an air bubble in a bulk metal without disturbing the external conductive thermal flux. The cloak is made of a thin layer of homogeneous and isotropic material with specially designed three-dimensional manufacturing. The cloak's thickness is $100\text{ }\text{ }\ensuremath{\mu}\mathrm{m}$ while the cloaked air bubble has a diameter of 1 cm, achieving the ratio between dimensions of the cloak and the cloaked object 2 orders smaller than previous thermal cloaks, which were mainly realized in a two-dimensional geometry. This work can find applications in novel thermal devices in the three-dimensional physical space.

https://physics.aps.org/featured-article-pdf/10.1103/PhysRevLett.112.054301

Fei Gao

Papers

Topological Acoustics

Acoustic higher-order topological insulator on a kagome lattice.

Probing topological protection using a designer surface plasmon structure.

Topologically protected refraction of robust kink states in valley photonic crystals

Ultrathin Three-Dimensional Thermal Cloak