F
Felix Ellett
Researcher at Harvard University
Publications - 70
Citations - 3253
Felix Ellett is an academic researcher from Harvard University. The author has contributed to research in topics: Inflammation & Biology. The author has an hindex of 24, co-authored 56 publications receiving 2515 citations. Previous affiliations of Felix Ellett include Walter and Eliza Hall Institute of Medical Research & University of Sheffield.
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Journal ArticleDOI
mpeg1 promoter transgenes direct macrophage-lineage expression in zebrafish
TL;DR: These zebrafish transgenes provide a new resource that will contribute to the fields of inflammation, infection, and leukocyte biology and help clarify the dynamic behaviors of neutrophils and macrophages after wounding.
Journal ArticleDOI
Infection of zebrafish embryos with intracellular bacterial pathogens
Erica L. Benard,Astrid M. van der Sar,Felix Ellett,Graham J. Lieschke,Herman P. Spaink,Annemarie H. Meijer +5 more
TL;DR: Detailed protocols for intravenous and local infection of zebrafish embryos with S. typhimurium or M. marinum bacteria and for subsequent fluorescence imaging of the interaction with cells of the innate immune system are described.
Journal ArticleDOI
Immunoresponsive Gene 1 Augments Bactericidal Activity of Macrophage-Lineage Cells by Regulating β-Oxidation-Dependent Mitochondrial ROS Production
Christopher J. Hall,Rachel H. Boyle,Jonathan W. Astin,Maria Vega Flores,Stefan H. Oehlers,Leslie E. Sanderson,Felix Ellett,Graham J. Lieschke,Kathryn E. Crosier,Philip S. Crosier +9 more
TL;DR: A role for the mitochondria-localizing enzyme encoded by Immunoresponsive gene 1 (IRG1) during the utilization of fatty acids as a fuel for oxidative phosphorylation (OXPHOS) and associated mROS production is described.
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Real-time whole-body visualization of Chikungunya Virus infection and host interferon response in zebrafish.
Nuno Palha,Florence Guivel-Benhassine,Florence Guivel-Benhassine,Valérie Briolat,Valérie Briolat,Georges Lutfalla,Georges Lutfalla,Marion Sourisseau,Marion Sourisseau,Felix Ellett,Chieh-Huei Wang,Graham J. Lieschke,Philippe Herbomel,Philippe Herbomel,Olivier Schwartz,Olivier Schwartz,Jean-Pierre Levraud,Jean-Pierre Levraud +17 more
TL;DR: A novel CHikungunya Virus infection model in zebrafish is described, where viral spread was live-imaged in the whole body up to cellular resolution, and it is demonstrated that neutrophils play a crucial, unexpected role in CHIKV containment.
Journal ArticleDOI
PGE2 production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo
Catherine A. Loynes,Jou A. Lee,Anne L. Robertson,Anne L. Robertson,Michael J. G. Steel,Felix Ellett,Felix Ellett,Yi Feng,Bruce D. Levy,Moira K. B. Whyte,Stephen A. Renshaw +10 more
TL;DR: Regulation of neutrophil migration by PGE2 and LXA4 (lipoxin A4) in an in vivo model of inflammation resolution is confirmed and this pathway may contain therapeutic targets for driving inflammation resolution in chronic inflammatory disease.