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Felix Rintelen
Researcher at Merck Serono
Publications - 2
Citations - 886
Felix Rintelen is an academic researcher from Merck Serono. The author has contributed to research in topics: Cancer & T cell. The author has an hindex of 2, co-authored 2 publications receiving 844 citations.
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Journal ArticleDOI
Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
Montserrat Camps,Thomas Rückle,Hong Ji,Vittoria Ardissone,Felix Rintelen,Jeffrey P. Shaw,Chiara Ferrandi,Christian Chabert,Corine Gillieron,Bernard Françon,Thierry Martin,Denise Gretener,Dominique Perrin,Didier Leroy,Pierre-Alain Vitte,Emilio Hirsch,Matthias P. Wymann,Rocco Cirillo,Matthias Schwarz,Christian Rommel +19 more
TL;DR: It is shown that Pik3cg−/− mice are largely protected in mouse models of rheumatoid arthritis; this protection correlates with defective neutrophil migration, further validating PI3Kγ as a therapeutic target.
Journal ArticleDOI
Inactivation of PI3Kgamma and PI3Kdelta distorts T-cell development and causes multiple organ inflammation.
Hong Ji,Felix Rintelen,Caroline Waltzinger,Dominique Bertschy Meier,Antonio Bilancio,Wayne Pearce,Emilio Hirsch,Matthias P. Wymann,Thomas Rückle,Montserrat Camps,Bart Vanhaesebroeck,Klaus Okkenhaug,Christian Rommel +12 more
TL;DR: It is demonstrated that in mature T cells, p110delta, but not p110gamma, controls Th1 and Th2 cytokine secretion, and the pathology in the p110gammadelta-deficient mice is likely to be secondary to a developmental block in the thymus that leads to lymphopenia-associated inflammatory responses.