W
Wayne Pearce
Researcher at University College London
Publications - 32
Citations - 4520
Wayne Pearce is an academic researcher from University College London. The author has contributed to research in topics: PI3K/AKT/mTOR pathway & Cancer. The author has an hindex of 24, co-authored 30 publications receiving 4111 citations. Previous affiliations of Wayne Pearce include Ludwig Institute for Cancer Research & Queen Mary University of London.
Papers
More filters
Journal ArticleDOI
Impaired B and T Cell Antigen Receptor Signaling in p110δ PI 3-Kinase Mutant Mice
Klaus Okkenhaug,Antonio Bilancio,Géraldine Farjot,Helen Priddle,Sara Sancho,Emma Peskett,Wayne Pearce,Stephen Meek,Ashreena Salpekar,Michael D. Waterfield,Michael D. Waterfield,Andrew J.H. Smith,Bart Vanhaesebroeck,Bart Vanhaesebroeck +13 more
TL;DR: Results reveal a selective role for p110δ in immunity and suggest second messenger signals downstream of tyrosine kinases influence cell metabolism, growth, proliferation, differentiation, motility, and survival.
Journal ArticleDOI
Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration
Mariona Graupera,Julie Guillermet-Guibert,Lazaros C. Foukas,Li-Kun Phng,Robert J. Cain,Ashreena Salpekar,Wayne Pearce,Stephen Meek,Jaime Millan,Pedro R. Cutillas,Andrew J.H. Smith,Anne J. Ridley,Christiana Ruhrberg,Holger Gerhardt,Bart Vanhaesebroeck +14 more
TL;DR: It is shown that only p110α activity is essential for vascular development and the first in vivo evidence for p110-isoform selectivity in endothelial PI3K signalling during angiogenesis is provided.
Journal ArticleDOI
Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation
Lazaros C. Foukas,Marc Claret,Wayne Pearce,Klaus Okkenhaug,Klaus Okkenhaug,Stephen Meek,Emma Peskett,Sara Sancho,Andrew J.H. Smith,Dominic J. Withers,Bart Vanhaesebroeck,Bart Vanhaesebroeck +11 more
TL;DR: A critical role for p110 α in growth factor and metabolic signalling is demonstrated and an explanation for selective mutation or overexpression of p110α in a variety of cancers is suggested.
Journal ArticleDOI
Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer
Khaled Ali,Dalya R. Soond,Roberto Piñeiro,Thorsten Hagemann,Wayne Pearce,Ee Lyn Lim,Hicham Bouabe,Cheryl L. Scudamore,Timothy Hancox,Heather Maecker,Lori Friedman,Martin R Turner,Klaus Okkenhaug,Bart Vanhaesebroeck +13 more
TL;DR: It is reported that p110δ inactivation in mice protects against a broad range of cancers, including non-haematological solid tumours, and can break tumour-induced immune tolerance and should be considered for wider use in oncology.
Journal ArticleDOI
Essential role for the p110δ phosphoinositide 3-kinase in the allergic response
Khaled Ali,Antonio Bilancio,Matthew Thomas,Wayne Pearce,Alasdair M. Gilfillan,Christine Tkaczyk,Nicolas Kuehn,Alexander Gray,June Giddings,Emma Peskett,Roy Fox,Ian N. Bruce,Christoph Walker,Carol Sawyer,Klaus Okkenhaug,Klaus Okkenhaug,Peter Finan,Bart Vanhaesebroeck,Bart Vanhaesebroeck +18 more
TL;DR: It is reported that genetic or pharmacological inactivation of the p110δ isoform of PI(3)K in mast cells leads to defective SCF-mediated in vitro proliferation, adhesion and migration, and to impaired allergen–IgE-induced degranulation and cytokine release.