C
Corine Gillieron
Researcher at Merck KGaA
Publications - 13
Citations - 2992
Corine Gillieron is an academic researcher from Merck KGaA. The author has contributed to research in topics: MAP kinase kinase kinase & MAP2K7. The author has an hindex of 12, co-authored 13 publications receiving 2897 citations.
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Journal ArticleDOI
Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
Montserrat Camps,Thomas Rückle,Hong Ji,Vittoria Ardissone,Felix Rintelen,Jeffrey P. Shaw,Chiara Ferrandi,Christian Chabert,Corine Gillieron,Bernard Françon,Thierry Martin,Denise Gretener,Dominique Perrin,Didier Leroy,Pierre-Alain Vitte,Emilio Hirsch,Matthias P. Wymann,Rocco Cirillo,Matthias Schwarz,Christian Rommel +19 more
TL;DR: It is shown that Pik3cg−/− mice are largely protected in mouse models of rheumatoid arthritis; this protection correlates with defective neutrophil migration, further validating PI3Kγ as a therapeutic target.
Journal ArticleDOI
Catalytic Activation of the Phosphatase MKP-3 by ERK2 Mitogen-Activated Protein Kinase
Montserrat Camps,Anthony Nichols,Corine Gillieron,Bruno Antonsson,Marco Muda,Christian Chabert,Ursula Boschert,Steve Arkinstall +7 more
TL;DR: Another homologous but nonselective phosphatase, MKP-4, bound and was activated by ERK2, JNK/SAPK, and p38 MAP kinases and was resistant to enzymatic inactivation by MKP.
Journal ArticleDOI
Bcl-2 Undergoes Phosphorylation by c-Jun N-terminal Kinase/Stress-activated Protein Kinases in the Presence of the Constitutively Active GTP-binding Protein Rac1
Kinsey Maundrell,Bruno Antonsson,Edith Magnenat,Montserrat Camps,Marco Muda,Christian Chabert,Corine Gillieron,Ursula Boschert,Elizabeth Vial-Knecht,Jean-Claude Martinou,Steve Arkinstall +10 more
TL;DR: This is the first report of Bcl-2 phosphorylation by the JNK/SAPK class of MAP kinases and could indicate a key modification allowing control of B cl-2 function by cell surface receptors, Rho family GTPases, and/or cellular stresses.
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The Dual Specificity Phosphatases M3/6 and MKP-3 Are Highly Selective for Inactivation of Distinct Mitogen-activated Protein Kinases
Marco Muda,Aspasia Theodosiou,Nanda R. Rodrigues,Ursula Boschert,Montserrat Camps,Corine Gillieron,Kay E. Davies,Alan Ashworth,Steve Arkinstall +8 more
TL;DR: Two new dual specificity phosphatases of the CL100/MKP-1 family that are selective for inactivating ERK or JNK/SAPK and p38 MAP kinases when expressed in COS-7 cells are described.
Journal ArticleDOI
Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1
Kate L. Jeffrey,Kate L. Jeffrey,Tilman Brummer,Michael S. Rolph,Michael S. Rolph,Sue M. Liu,Sue M. Liu,Nuria A Callejas,Raelene J. Grumont,Corine Gillieron,Fabienne Mackay,Shane T. Grey,Montserrat Camps,Christian Rommel,Steve Gerondakis,Charles R. Mackay,Charles R. Mackay +16 more
TL;DR: PAC-1 is a key positive regulator of inflammatory cell signaling and effector functions, mediated through Jnk and Erk mitogen-activated protein kinase crosstalk.