Felix Schürmann

TL;DR: A first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat is presented, finding a spectrum of network states with a sharp transition from synchronous to asynchronous activity, modulated by physiological mechanisms.

TL;DR: Key features of the somatic and dendritic firing of L5b pyramidal cells in adult rats are characterized and a useful way to analyze model parameters with their sets of models is shown, which enabled them to identify some of the mechanisms responsible for the dynamic properties of L 5b pyramsidal cells as well as mechanisms that are sensitive to morphological changes.

TL;DR: It is argued that the multiple, diverse models generated by this method could serve as the building blocks for the realistic simulation of large neuronal networks.

TL;DR: It is found that random alignment of axonal and dendritic arbors provides a sufficient foundation for specific functional connectivity to emerge in local neural microcircuits, suggesting that chemospecific steering and aligning of the arbors may occur for some types of connections.

TL;DR: A multi-constraint, data-driven process to digitally reconstruct, and simulate prototypical neocortical microcircuitry, using sparse experimental data is established and considered a major step in the development of in silica neuroscience.