Michael Gevaert

TL;DR: A first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat is presented, finding a spectrum of network states with a sharp transition from synchronous to asynchronous activity, modulated by physiological mechanisms.

TL;DR: A multi-constraint, data-driven process to digitally reconstruct, and simulate prototypical neocortical microcircuitry, using sparse experimental data is established and considered a major step in the development of in silica neuroscience.

TL;DR: BluePyOpt is an extensible framework for data-driven model parameter optimisation that wraps and standardizes several existing open-source tools and simplifies the task of creating and sharing these optimisations, and the associated techniques and knowledge.

TL;DR: The BluePyOpt framework as discussed by the authors is an extensible framework for data-driven model parameter optimisation that wraps and standardises several existing open-source tools to simplify the task of creating and sharing these optimisations, and the associated techniques and knowledge.

TL;DR: The Scalable Open Network Architecture TemplAte (SONATA) data format is designed for memory and computational efficiency and works across multiple platforms and provides much flexibility for adding new conventions or extensions.