Sendoa Tajada

TL;DR: This work shows that LPS exerts fast, membrane delimited, excitatory actions via TRPA1, a transient receptor potential cation channel that is critical for transducing environmental irritant stimuli into nociceptor activity, and finds that pain and acute vascular reactions, including neurogenic inflammation (CGRP release) caused by LPS are primarily dependent onTRPA1 channel activation in nocICEptive sensory neurons, and develop independently of TLR4 activation.

TL;DR: These findings suggest that the signaling cascade linking Kv1.3 functional expression to cell proliferation is activated by the voltage-dependent conformational change of the channels without needing ion conduction.

TL;DR: It is proposed that cooperative gating of CaV1.3S channels represents a mechanism for the regulation of Ca2+ signaling and electrical activity, leading to increased firing rates in rat hippocampal neurons.

TL;DR: This review focuses in the role of calcium permeable channels signaling in cancer with special attention to the mechanisms behind the remodeling of the calcium signals.

TL;DR: It is shown that the role of BIN1 during the differentiation of hESC‐CMs is also important for CaV1.2 channel clustering, junctional SR organization, and the establishment of excitation–contraction coupling.