Rosa Señarís

TL;DR: This work shows that LPS exerts fast, membrane delimited, excitatory actions via TRPA1, a transient receptor potential cation channel that is critical for transducing environmental irritant stimuli into nociceptor activity, and finds that pain and acute vascular reactions, including neurogenic inflammation (CGRP release) caused by LPS are primarily dependent onTRPA1 channel activation in nocICEptive sensory neurons, and develop independently of TLR4 activation.

TL;DR: The aim of the present study was to study whether leptin can act as a metabolic signal connecting the adipose tissue with the growth hormone axis and decrease in spontaneous GH secretion.

TL;DR: Leptin is synthesized as a single molecular variant identical to human recombinant leptin in human placentae at delivery, indicating that intact leptin was found and no variants in size, charge or immunoactivity were present in the Placentae.

TL;DR: Ghrelin, the endogenous ligand of the GH secretagogue receptor, acts at central level to elicit GH release and regulate food intake in adult male rats, fed or fasted for 72 h, were treated centrally (intracerebroventicularly) with a single dose of ghrelin (5 μg).

TL;DR: The results indicate that leptin inhibits a fasting-induced increase in prepro-orexin mRNA and orexin receptor 1 mRNA levels in the rat hypothalamus, while orexIn receptor 2 mRNA levels were unchanged in all situations evaluated.