다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

The reference human genome sequence set the stage for studies of genetic variation and its association with human disease, but epigenomic studies lack a similar reference. To address this need, the NIH Roadmap Epigenomics Consortium generated the largest collection so far of human epigenomes for primary cells and tissues. Here we describe the integrative analysis of 111 reference human epigenomes generated as part of the programme, profiled for histone modification patterns, DNA accessibility, DNA methylation and RNA expression. We establish global maps of regulatory elements, define regulatory modules of coordinated activity, and their likely activators and repressors. We show that disease- and trait-associated genetic variants are enriched in tissue-specific epigenomic marks, revealing biologically relevant cell types for diverse human traits, and providing a resource for interpreting the molecular basis of human disease. Our results demonstrate the central role of epigenomic information for understanding gene regulation, cellular differentiation and human disease.

Integrative analysis of 111 reference human epigenomes

Bevacizumab plus Irinotecan,Fluorouracil,and Leucovorin for Metastatic Colorectal Cancer

Review of recent research on hepatitis C therapy for 54th annual meeting of the American association for the study of liver diseases

正しい方法がわかる臨床基本手技 : from the New England journal of medicine

Zi-Xiang CHEN, Lan-Qing YAO, Li-Hui GU, Lei LIANG, Ping WANG, Matteo CESCON, Dong-Sheng HUANG, Timothy M. PAWLIK, Wan Yee LAU, Feng SHEN, Fu-Bao LIU, Tian YANG*. Ann Hepatobiliary Pancreat Surg 2022;26:S312. https://doi.org/10.14701/ahbps.2022S1.EP-30 

https://www.ahbps.org/journal/download_pdf.php?doi=10.14701/ahbps.2022S1.EP-30

Development and validation of a safety and efficacy-associated risk calculator for hepatocellular carcinoma in the elderly after resection (SEARCHER): An international multicenter study

Chao LI, Hao XING, Yong-Kang DIAO, Lan-Qing YAO, Xiao XU, Hang-Dong JIA, Yong-Yi ZENG, Xian-Ming WANG, Feng SHEN, Tian YANG*. Ann Hepatobiliary Pancreat Surg 2023;27:S186. https://doi.org/10.14701/ahbps.2023S1.LV-PP-3-7 

https://www.ahbps.org/journal/download_pdf.php?doi=10.14701/ahbps.2023S1.LV-PP-3-7

Feng Shen

Papers

Development and validation of a safety and efficacy-associated risk calculator for hepatocellular carcinoma in the elderly after resection (SEARCHER): An international multicenter study

Validation of the french afp model as a predictor of recurrence following hepatectomy for hepatocellular carcinoma a large multicenter cohort study

Predictors and Prognostic Significance of Postoperative Complications for Patients with Intrahepatic Cholangiocarcinoma