Filip Meersman

TL;DR: All the fragments are rather resistant to heat‐induced denaturation, and display high conformational stabilities, which has never been reported for any functional conventional antibody fragment, even when engineered antigen binders are considered.

TL;DR: The cold unfolding of myoglobin is studied with Fourier transform infrared spectroscopy and compared it with pressure and heat unfolding to suggest that the pathways of the cold and pressure unfolding are substantially different from that of the heat unfolding.

TL;DR: In this review, recent and emerging applications of high pressure in biotechnology are presented and discussed.

TL;DR: The notion that amyloid fibrils can represent the global minimum in free energy is supported by this type of investigations, which suggests that a temporal transition occurs during which side chain packing and hydrogen bond formation are optimised, whereas the hydrophobic effect and electrostatic interactions play a dominant role in the early stages of the aggregation.

TL;DR: The functional divergence of former alleles observed here suggests that adoption of asexual reproduction could itself be an evolutionary mechanism for the generation of diversity.