F
Flavia Cassiola
Researcher at Boston Children's Hospital
Publications - 6
Citations - 1821
Flavia Cassiola is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Sunitinib & Angiogenesis. The author has an hindex of 6, co-authored 6 publications receiving 1679 citations.
Papers
More filters
Journal ArticleDOI
Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib
Tammy F. Chu,Tammy F. Chu,Maria Rupnick,Maria Rupnick,Risto Kerkelä,Susan M. Dallabrida,David Zurakowski,Lisa Nguyen,Kathleen C. Woulfe,Elke Pravda,Flavia Cassiola,Jayesh Desai,Suzanne George,David M. Harris,Nesreen S. Ismail,Jey-Hsin Chen,Frederick J. Schoen,Annick D. Van den Abbeele,George D. Demetri,Thomas Force,Ming-Hui Chen,Ming-Hui Chen,Jeffrey A. Morgan +22 more
TL;DR: Left ventricular dysfunction might be due, in part, to direct cardiomyocyte toxicity, exacerbated by hypertension, and patients treated with sunitinib should be closely monitored for hypertension and LVEF reduction, especially those with a history of coronary artery disease or cardiac risk factors.
Journal ArticleDOI
Platelets actively sequester angiogenesis regulators
Giannoula Klement,Giannoula Klement,Tai-Tung Yip,Flavia Cassiola,Lena Kikuchi,David Cervi,Vladimir N. Podust,Joseph E. Italiano,Joseph E. Italiano,Erin Wheatley,Abdo Abou-Slaybi,Elise Bender,Nava Almog,Mark W. Kieran,Mark W. Kieran,Judah Folkman +15 more
TL;DR: It is shown that accumulation of angiogenesis regulators in platelets of animals bearing malignant tumors exceeds significantly their concentration in plasma or serum, as well as their levels in Platelets from non-tumor-bearing animals.
Journal ArticleDOI
Nanomagnetic actuation of receptor-mediated signal transduction.
Robert Mannix,Sanjay Kumar,Sanjay Kumar,Flavia Cassiola,Martin Montoya-Zavala,Efraim Feinstein,Mara Prentiss,Donald E. Ingber +7 more
TL;DR: A magnetic nanotechnology that activates a biochemical signalling mechanism normally switched on by binding of multivalent chemical ligands, and may represent a new actuator mechanism for cell-based microtechnologies and man-machine interfaces.
Journal ArticleDOI
An orally delivered small-molecule formulation with antiangiogenic and anticancer activity
Ofra Benny,Ofer Fainaru,Avner Adini,Flavia Cassiola,Lauren Bazinet,Irit Adini,Elke Pravda,Yaakov Nahmias,Samir Koirala,Gabriel Corfas,Robert J. D'Amato,Judah Folkman +11 more
TL;DR: Lodamin is an oral nontoxic antiangiogenic drug that can be chronically administered for cancer therapy or metastasis prevention and first reaches the liver, making it especially efficient in preventing the development of liver metastasis in mice.
Journal ArticleDOI
Cellular mechanism of oral absorption of solidified polymer micelles
Eva Abramov,Flavia Cassiola,Ouri Schwob,Adi Karsh-Bluman,Mara Shapero,J. S. Ellis,Dema Luyindula,Irit Adini,Robert J. D'Amato,Ofra Benny +9 more
TL;DR: Monomethoxy polyethylene glycol-poly lactic acid micelles are developed as a drug nanocarrier, and the mechanism of uptake across intestinal cells is studied, finding that mPEG-PLA nanoparticle endocytosis is mediated by clathrin in an energy-dependent manner, and that the low-density lipoprotein receptor is involved.