F
Florence Gross
Researcher at McGill University
Publications - 8
Citations - 250
Florence Gross is an academic researcher from McGill University. The author has contributed to research in topics: G protein-coupled receptor & Drug discovery. The author has an hindex of 6, co-authored 7 publications receiving 131 citations. Previous affiliations of Florence Gross include Université de Montréal.
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Journal ArticleDOI
Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons.
Aliza T. Ehrlich,Meriem Semache,Florence Gross,Florence Gross,Dillon F. Da Fonte,Leonie Runtz,Christine Colley,Christine Colley,Amina Mezni,Amina Mezni,Christian Le Gouill,Viktoriya Lukasheva,Mireille Hogue,Emmanuel Darcq,Michel Bouvier,Brigitte L. Kieffer +15 more
TL;DR: This work selected a set of clinical and novel mu agonists, and profiled their activities in transfected cell assays using advanced biosensors and in native neurons from knock-in mice expressing traceable receptors endogenously, supporting in vivo translatability of biased signaling for mu opioid drugs.
Posted ContentDOI
Selectivity Landscape of 100 Therapeutically Relevant GPCR Profiled by an Effector Translocation-Based BRET Platform
Charlotte Avet,Arturo Mancini,Billy Breton,Christian Le Gouill,Alexander S. Hauser,Claire Normand,Hiroyuki Kobayashi,Florence Gross,Mireille Hogue,Viktoriya Lukasheva,Sandra Morissette,Eric B. Fauman,Jean-Philippe Fortin,Stephan Schann,Xavier Leroy,David E. Gloriam,Michel Bouvier +16 more
TL;DR: A new BRET-based effector membrane translocation assay (EMTA) is used that monitors activation of each Gα protein through the recruitment of selective G protein effectors and βarrestins to the plasma membrane, providing a new tool for safety screens and systems pharmacology.
Posted ContentDOI
Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs
Charlotte Avet,Arturo Mancini,Billy Breton,Christian Le Gouill,Alexander S. Hauser,Claire Normand,Hiroyuki Kobayashi,Florence Gross,Mireille Hogue,Viktoriya Lukasheva,Stéphane St-Onge,Marilyn Carrier,Madeleine Héroux,Sandra Morissette,Eric B. Fauman,Jean-Philippe Fortin,Stephan Schann,Xavier Leroy,David E. Gloriam,Michel Bouvier +19 more
TL;DR: In this article, a set of BRET sensors monitoring the activation of the 12 G protein subtypes based on the translocation of their effectors to the plasma membrane (EMTA) was presented.
Journal ArticleDOI
Rare susceptibility variants for bipolar disorder suggest a role for G protein-coupled receptors.
Cristiana Cruceanu,Cristiana Cruceanu,Schmouth Jf,Susana G. Torres-Platas,Juan Pablo Lopez,Amirthagowri Ambalavanan,Emmanuel Darcq,Florence Gross,Breton B,Dan Spiegelman,Daniel Rochefort,Pascale Hince,Joanne Petite,Julie Gauthier,Lafrenière Rg,Patrick A. Dion,Celia M. T. Greenwood,Celia M. T. Greenwood,Brigitte L. Kieffer,Martin Alda,Gustavo Turecki,Guy A. Rouleau +21 more
TL;DR: Key biochemical pathways likely implicated in this complex disorder are identified by focusing on rare variants in informative families and targeted downstream GPCR dysregulation for some of the variants that may contribute to disease pathology.
Journal ArticleDOI
Mapping GPR88-Venus illuminates a novel role for GPR88 in sensory processing.
Aliza T. Ehrlich,Meriem Semache,Julie Bailly,Stefan Wojcik,Stefan Wojcik,Tanzil Mahmud Arefin,Christine Colley,Christine Colley,Christian Le Gouill,Florence Gross,Florence Gross,Viktoriya Lukasheva,Mireille Hogue,Emmanuel Darcq,Laura-Adela Harsan,Laura-Adela Harsan,Michel Bouvier,Brigitte L. Kieffer +17 more
TL;DR: The data show for the first time a prominent role for GPR88 in multisensory processing, and definitely positions Gpr88 as a target to treat mental disorders perhaps via activity on cortical sensory networks.