F
Florencio Porto Freitas
Researcher at University of São Paulo
Publications - 17
Citations - 2257
Florencio Porto Freitas is an academic researcher from University of São Paulo. The author has contributed to research in topics: GPX4 & Chemistry. The author has an hindex of 8, co-authored 12 publications receiving 1043 citations. Previous affiliations of Florencio Porto Freitas include University of Würzburg.
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Journal ArticleDOI
FSP1 is a glutathione-independent ferroptosis suppressor
Sebastian Doll,Florencio Porto Freitas,Ron Shah,Maceler Aldrovandi,Milene Costa da Silva,Irina Ingold,Andrea Goya Grocin,Thamara Nishida Xavier da Silva,Elena Panzilius,Christina Scheel,André Mourão,Katalin Buday,Mami Sato,Jonas Wanninger,Thibaut Vignane,Vaishnavi Mohana,Markus Rehberg,Andrew Flatley,Aloys Schepers,Andreas Kurz,Daniel A. White,Markus Sauer,Michael Sattler,Edward W. Tate,Werner Schmitz,Almut Schulze,Valerie B. O'Donnell,Bettina Proneth,Grzegorz M. Popowicz,Derek A. Pratt,José Pedro Friedmann Angeli,Marcus Conrad +31 more
TL;DR: The FSP1–CoQ10–NAD(P)H pathway exists as a stand-alone parallel system, which co-operates with GPX4 and glutathione to suppress phospholipid peroxidation and ferroptosis in cells.
Journal ArticleDOI
Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis
Irina Ingold,Carsten Berndt,Sabine Schmitt,Sebastian Doll,Gereon Poschmann,Katalin Buday,Antonella Roveri,Xiaoxiao Peng,Florencio Porto Freitas,Tobias Seibt,Lisa Mehr,Michaela Aichler,Axel Walch,Daniel Lamp,Martin Jastroch,Sayuri Miyamoto,Wolfgang Wurst,Wolfgang Wurst,Fulvio Ursini,Elias S.J. Arnér,Noelia Fradejas-Villar,Ulrich Schweizer,Hans Zischka,José Pedro Friedmann Angeli,Marcus Conrad +24 more
TL;DR: It is demonstrated that selenolate-based catalysis of the essential mammalian selenoprotein GPX4 is unexpectedly dispensable for normal embryogenesis and the survival of a specific type of interneurons emerges to exclusively depend on selenocysteine-containing GPX 4, thereby preventing fatal epileptic seizures.
Journal ArticleDOI
[13C2]- Acetaldehyde Promotes Unequivocal Formation of 1,N2-Propano-2′-deoxyguanosine in Human Cells
Camila Carrião Machado Garcia,José Pedro Friedmann Angeli,Florencio Porto Freitas,Osmar F. Gomes,de Oliveira Tf,Ana Paula de Melo Loureiro,Di Mascio P,Marisa H. G. Medeiros +7 more
TL;DR: The unequivocal formation of 1,N(2)-propanodGuo in cells exposed to this aldehyde can be used to elucidate the mechanisms associated with acetaldehyde exposure and cancer risk.
Journal ArticleDOI
Lipid hydroperoxide-induced and hemoglobin-enhanced oxidative damage to colon cancer cells.
José Pedro Friedmann Angeli,Camila Carrião Machado Garcia,Fernanda Sena,Florencio Porto Freitas,Sayuri Miyamoto,Marisa Helena Gennari de Medeiros,Paolo Di Mascio +6 more
TL;DR: Hb from either red meat or bowel bleeding could act as an enhancer of fatty acid hydroperoxide genotoxicity, which contributes to the accumulation of DNA lesions in colon cancer cells.
Journal ArticleDOI
Evaluation of chemical constituents and antioxidant activity of coconut water (Cocus nucifera L.) and caffeic acid in cell culture.
João L. A. Santos,Vanderson S. Bispo,Adriano de Britto Chaves Filho,Isabella Fernanda Dantas Pinto,Lucas S. Dantas,Daiane F. Vasconcelos,Fabíula F. Abreu,Danilo A. Melo,Isaac A. Matos,Florencio Porto Freitas,Osmar F. Gomes,Marisa Helena Gennari de Medeiros,Humberto R. Matos +12 more
TL;DR: The green dwarf water was efficient in protecting against oxidative damages induced by hydrogen peroxide, highlighting the antioxidant properties of the green dwarf which it is the most common used.