M
Mami Sato
Researcher at Niigata University
Publications - 9
Citations - 1627
Mami Sato is an academic researcher from Niigata University. The author has contributed to research in topics: Immunology & Medicine. The author has an hindex of 5, co-authored 6 publications receiving 684 citations. Previous affiliations of Mami Sato include Yamagata University.
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Journal ArticleDOI
FSP1 is a glutathione-independent ferroptosis suppressor
Sebastian Doll,Florencio Porto Freitas,Ron Shah,Maceler Aldrovandi,Milene Costa da Silva,Irina Ingold,Andrea Goya Grocin,Thamara Nishida Xavier da Silva,Elena Panzilius,Christina Scheel,André Mourão,Katalin Buday,Mami Sato,Jonas Wanninger,Thibaut Vignane,Vaishnavi Mohana,Markus Rehberg,Andrew Flatley,Aloys Schepers,Andreas Kurz,Daniel A. White,Markus Sauer,Michael Sattler,Edward W. Tate,Werner Schmitz,Almut Schulze,Valerie B. O'Donnell,Bettina Proneth,Grzegorz M. Popowicz,Derek A. Pratt,José Pedro Friedmann Angeli,Marcus Conrad +31 more
TL;DR: The FSP1–CoQ10–NAD(P)H pathway exists as a stand-alone parallel system, which co-operates with GPX4 and glutathione to suppress phospholipid peroxidation and ferroptosis in cells.
Journal ArticleDOI
The ferroptosis inducer erastin irreversibly inhibits system x c − and synergizes with cisplatin to increase cisplatin’s cytotoxicity in cancer cells
Mami Sato,Ryosuke Kusumi,Shinji Hamashima,Sho Kobayashi,Satoru Sasaki,Yuhei Komiyama,Takuji Izumikawa,Marcus Conrad,Shiro Bannai,Hideyo Sato +9 more
TL;DR: It is suggested that only a very short pre-treatment of erastin suffices to synergize with cisplatin to efficiently induce cancer cell death, findings that might guide the design of novel cancer treatment paradigms.
Journal ArticleDOI
Sorafenib fails to trigger ferroptosis across a wide range of cancer cell lines
TL;DR: In this paper, a combination of well-defined genetically engineered tumor cell lines and canonical small molecule ferroptosis inhibitors was used to show that sorafenib does not induce a significant fraction of tumor cells to die from ferroPTosis when compared to sulfasalazine and erastin.
Journal ArticleDOI
Cystathionine Is a Novel Substrate of Cystine/Glutamate Transporter IMPLICATIONS FOR IMMUNE FUNCTION
Sho Kobayashi,Mami Sato,Takayuki Kasakoshi,Takumi Tsutsui,Masahiro Sugimoto,Mitsuhiko Osaki,Futoshi Okada,Kiharu Igarashi,Jun Hiratake,Takujiro Homma,Marcus Conrad,Junichi Fujii,Tomoyoshi Soga,Shiro Bannai,Hideyo Sato +14 more
TL;DR: It is concluded that cystathionine is a novel physiological substrate of system xc− and that the accumulation of cystATHionine in immune tissues is exclusively mediated by system x c−.
Journal ArticleDOI
Loss of the cystine/glutamate antiporter in melanoma abrogates tumor metastasis and markedly increases survival rates of mice.
Mami Sato,Kunishige Onuma,Kunishige Onuma,Mio Domon,Shun Hasegawa,Ami Suzuki,Ryosuke Kusumi,Remi Hino,Nahoko Kakihara,Yusuke Kanda,Mitsuhiko Osaki,Junichi Hamada,Shiro Bannai,Regina Feederle,Katalin Buday,José Pedro Friedmann Angeli,Bettina Proneth,Marcus Conrad,Futoshi Okada,Hideyo Sato +19 more
TL;DR: System xc− emerges to be essential for tumor metastasis in mice, thus qualifying as a highly attractive anticancer drug target, particularly in light of its dispensable role for normal life in mice.