F
Francesc X. Guix
Researcher at Spanish National Research Council
Publications - 31
Citations - 1460
Francesc X. Guix is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Peroxynitrite & Amyloid precursor protein. The author has an hindex of 16, co-authored 28 publications receiving 1306 citations. Previous affiliations of Francesc X. Guix include Pompeu Fabra University & Katholieke Universiteit Leuven.
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Journal ArticleDOI
The physiology and pathophysiology of nitric oxide in the brain.
TL;DR: Nitric oxide is a well-known vasorelaxant agent, but it works as a neurotransmitter when produced by neurons and is also involved in defense functions when it is produced by immune and glial cells.
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Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation
Francesc X. Guix,Francesc X. Guix,Gerard ILL-Raga,Ramona Bravo,Tadashi Nakaya,Gianni De Fabritiis,Mireia Coma,Gian Pietro Miscione,Jordi Villà-Freixa,Toshiharu Suzuki,Xavier Fernàndez-Busquets,Miguel A. Valverde,Bart De Strooper,Francisco J. Muñoz +13 more
TL;DR: The results link oxidative stress, the main etiopathogenic mechanism in sporadic Alzheimer's disease, via the production of peroxynitrite and nitrotyrosination of triosephosphate isomerase, to amyloid beta-peptide-induced toxicity and tau pathology.
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Modification of γ‐secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease
Francesc X. Guix,Tina Wahle,Kristel M. Vennekens,An Snellinx,Lucía Chávez-Gutiérrez,Gerard ILL-Raga,Eva Ramos-Fernández,Cristina Guardia-Laguarta,Alberto Lleó,Muriel Arimon,Oksana Berezovska,Francisco J. Muñoz,Carlos G. Dotti,Carlos G. Dotti,Bart De Strooper +14 more
TL;DR: It is demonstrated that the secretion of Aβ is enhanced in an in vitro model of neuronal ageing, correlating with an increase in γ‐secretase complex formation, and nitrosative stress is identified as a potential mechanistic link between ageing and AD.
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Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments
Francesc X. Guix,Ragna Sannerud,Fedor Berditchevski,Amaia M. Arranz,Katrien Horré,An Snellinx,Amantha Thathiah,Takaomi C. Saido,Takashi Saito,Sundaresan Rajesh,Michael Overduin,Samir Kumar-Singh,Enrico Radaelli,Nikky Corthout,Julien Colombelli,Sébastien Tosi,Sebastian Munck,Isabel H. Salas,Wim Annaert,Bart De Strooper,Bart De Strooper +20 more
TL;DR: TSPAN 6 is a key player in the bifurcation between lysosomal-dependent degradation and exosome mediated secretion of APP-CTF, corroborates the central role of the autophagosomal/lysosomal pathway in APP metabolism and shows that TSPAN6 is a crucial player in APP- CTF turnover.
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Plasma membrane voltage-dependent anion channel mediates antiestrogen-activated maxi Cl- currents in C1300 neuroblastoma cells.
Maria I. Bahamonde,José M. Fernández-Fernández,Francesc X. Guix,Esther Vázquez,Miguel A. Valverde +4 more
TL;DR: The cellular localization of VDAC and its relationship with the antiestrogen-activated Maxi Cl– current in C1300 neuroblastoma cells is investigated and transfection of C13000 cells with an antisense oligonucleotide directed against the specific membrane leader sequence of VdAC markedly reduced both VDac immunostaining and antiestrogens-activatedMaxi Cl- currents, suggesting that VD AC forms the plasma membrane MaxiCl– channel or a part thereof