O
Oksana Berezovska
Researcher at Harvard University
Publications - 84
Citations - 5013
Oksana Berezovska is an academic researcher from Harvard University. The author has contributed to research in topics: Presenilin & Amyloid precursor protein. The author has an hindex of 39, co-authored 78 publications receiving 4690 citations. Previous affiliations of Oksana Berezovska include University of Saskatchewan & Brigham and Women's Hospital.
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Journal ArticleDOI
Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid β-peptide
Luigi Puglielli,Genevieve Konopka,Eunju Pack-Chung,Laura A. MacKenzie Ingano,Oksana Berezovska,Bradley T. Hyman,Ta-Yuan Chang,Rudolph E. Tanzi,Dora M. Kovacs +8 more
TL;DR: It is found that cholesteryl-ester levels are directly correlated with Aβ production, and pharmacological inhibitors of ACAT, developed for the treatment of atherosclerosis, are potent modulators of Aβ generation, indicating their potential for use in thereatment of Alzheimer's disease.
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γ-Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer's Disease
Lutgarde Serneels,Jérôme Van Biervliet,Katleen Craessaerts,Tim Dejaegere,Katrien Horré,Tine Van Houtvin,Hermann Esselmann,Hermann Esselmann,Sabine Paul,Sabine Paul,Martin K.-H. Schäfer,Oksana Berezovska,Bradley T. Hyman,Ben Sprangers,Raf Sciot,Lieve Moons,Mathias Jucker,Zhixiang Yang,Patrick C. May,Eric Karran,Jens Wiltfang,Jens Wiltfang,Rudi D'Hooge,Bart De Strooper +23 more
TL;DR: Specific inactivation of the Aph1B γ-secretase in a mouse Alzheimer's disease model led to improvements of Alzheimer’s disease–relevant phenotypic features without any Notch-related side effects, and thus specific targeting of Aph1 B-containing γ -secretase complexes may help generate less toxic therapies for Alzheimer”s disease.
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Notch1 inhibits neurite outgrowth in postmitotic primary neurons.
Oksana Berezovska,Pamela J. McLean,Roger B. Knowles,M. Frosh,F.M. Lu,Samuel E. Lux,Bradley T. Hyman +6 more
TL;DR: Results show that in postmitotic neurons Notch1 influences neurite morphology, and can activate its native signal transduction pathway, which strongly suggest that notch1 may play a physiologically important role in the central nervous system beyond neurogenesis.
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Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation.
Alberto Lleó,Oksana Berezovska,Lauren Herl,Susan Raju,Amy Deng,Brian J. Bacskai,Matthew P. Frosch,Michael C. Irizarry,Bradley T. Hyman +8 more
TL;DR: It is demonstrated, using a fluorescence resonance energy transfer method, that Aβ42-lowering NSAIDs specifically affect the proximity between APP and presenilin 1 and alter presenILin 1 conformation both in vitro and in vivo, suggesting a novel allosteric mechanism of action.
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CHIP Targets Toxic α-Synuclein Oligomers for Degradation
Julie E. Tetzlaff,Preeti Putcha,Tiago F. Outeiro,Alexander R. Ivanov,Oksana Berezovska,Bradley T. Hyman,Pamela J. McLean +6 more
TL;DR: It is found that co-expression of CHIP selectively reduced α-Synuclein oligomerization and toxicity in a tetratricopeptide domain-dependent, U-box-independent manner by specifically degrading toxic αSyn oligomers.