K
Katrien Horré
Researcher at Katholieke Universiteit Leuven
Publications - 29
Citations - 3813
Katrien Horré is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Amyloid precursor protein & Presenilin. The author has an hindex of 20, co-authored 26 publications receiving 3382 citations. Previous affiliations of Katrien Horré include Catholic University of Leuven & Allen Institute for Brain Science.
Papers
More filters
Journal ArticleDOI
Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression.
Sébastien S. Hébert,Katrien Horré,Laura Nicolaï,Aikaterini S. Papadopoulou,Wim Mandemakers,Asli Silahtaroglu,Sakari Kauppinen,Sakari Kauppinen,André Delacourte,Bart De Strooper +9 more
TL;DR: It is shown here that miR-29a, -29b-1, and -9 can regulate Bace1 expression in vitro and proposed that loss of specific miRNAs can contribute to increased BACE1 and Aβ levels in sporadic AD.
Journal ArticleDOI
Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
Mostafa Bentahir,Omar Nyabi,Jan Verhamme,Alexandra Tolia,Katrien Horré,Jens Wiltfang,Hermann Esselmann,Bart De Strooper +7 more
TL;DR: Overall, the results indicate that the different mutations in PS affect γ‐secretase structure or function in multiple ways.
Journal ArticleDOI
MicroRNA regulation of Alzheimer's Amyloid precursor protein expression
Sébastien S. Hébert,Katrien Horré,Laura Nicolaï,Bruno Bergmans,Aikaterini S. Papadopoulou,André Delacourte,Bart De Strooper +6 more
TL;DR: It is shown that miRNAs belonging to the miR-20a family could regulate APP expression in vitro and at the endogenous level in neuronal cell lines, suggesting that variations in miRNA expression could contribute to changes inAPP expression in the brain during development and disease.
Journal ArticleDOI
γ-Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer's Disease
Lutgarde Serneels,Jérôme Van Biervliet,Katleen Craessaerts,Tim Dejaegere,Katrien Horré,Tine Van Houtvin,Hermann Esselmann,Hermann Esselmann,Sabine Paul,Sabine Paul,Martin K.-H. Schäfer,Oksana Berezovska,Bradley T. Hyman,Ben Sprangers,Raf Sciot,Lieve Moons,Mathias Jucker,Zhixiang Yang,Patrick C. May,Eric Karran,Jens Wiltfang,Jens Wiltfang,Rudi D'Hooge,Bart De Strooper +23 more
TL;DR: Specific inactivation of the Aph1B γ-secretase in a mouse Alzheimer's disease model led to improvements of Alzheimer’s disease–relevant phenotypic features without any Notch-related side effects, and thus specific targeting of Aph1 B-containing γ -secretase complexes may help generate less toxic therapies for Alzheimer”s disease.
Journal ArticleDOI
Alzheimer's-causing mutations shift Aβ length by destabilizing γ-secretase-Aβn interactions.
Maria Szaruga,Bogdan Munteanu,Sam Lismont,Sarah Veugelen,Katrien Horré,Marc Mercken,Takaomi C. Saido,Natalie S. Ryan,Tatjana De Vos,Savvas N. Savvides,Rodrigo Gallardo,Joost Schymkowitz,Frederic Rousseau,Nick C. Fox,Carsten Hopf,Bart De Strooper,Bart De Strooper,Lucía Chávez-Gutiérrez +17 more
TL;DR: This work presents a unifying model for how PSEN or APP mutations enhance amyloidogenic Aβ production, suggests that environmental factors may increase AD risk, and provides the theoretical basis for the development of γ-secretase/substrate stabilizing compounds for the prevention of AD.