F
Francesca Zalfa
Researcher at Università Campus Bio-Medico
Publications - 34
Citations - 3083
Francesca Zalfa is an academic researcher from Università Campus Bio-Medico. The author has contributed to research in topics: RNA & Cancer. The author has an hindex of 20, co-authored 31 publications receiving 2671 citations. Previous affiliations of Francesca Zalfa include University of Rome Tor Vergata.
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Journal ArticleDOI
The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapses.
Francesca Zalfa,Marcello Giorgi,Beatrice Primerano,Annamaria Moro,Alessandra di Penta,Surya A. Reis,Ben A. Oostra,Claudia Bagni +7 more
TL;DR: It is shown that FMRP acts as a translational repressor of specific mRNAs at synapses, which could result in synaptic dysfunction phenotype of Fragile X patients when FMRp is not present.
Journal ArticleDOI
The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP.
Ilaria Napoli,Ilaria Napoli,Valentina Mercaldo,Pietro Pilo Boyl,Boris Eleuteri,Francesca Zalfa,Silvia De Rubeis,Silvia De Rubeis,Daniele Di Marino,Evita Mohr,Marzia Massimi,Mattia Falconi,Walter Witke,Mauro Costa-Mattioli,Nahum Sonenberg,Tilmann Achsel,Claudia Bagni +16 more
TL;DR: The fragile X mental retardation protein (FMRP) acts by inhibiting translation initiation, and the translational repression activity of FMRP in the brain is mediated, at least in part, by CYFIP1.
Journal ArticleDOI
A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability
Francesca Zalfa,Boris Eleuteri,Kirsten S. Dickson,Valentina Mercaldo,Silvia De Rubeis,Alessandra di Penta,Elisabetta Tabolacci,Pietro Chiurazzi,Giovanni Neri,Seth G. N. Grant,Seth G. N. Grant,Claudia Bagni +11 more
TL;DR: In mice, it is found that FMRP binds, in vivo, the mRNA encoding PSD-95, a key molecule that regulates neuronal synaptic signaling and learning, and evidence that dysregulation of mRNA stability may contribute to the cognitive impairments in individuals with FXS is provided.
Journal ArticleDOI
Clinical, pathological, and PAM50 gene expression features of HER2-low breast cancer.
Francesco Schettini,Francesco Schettini,Nuria Chic,Nuria Chic,Fara Brasó-Maristany,Fara Brasó-Maristany,Laia Paré,Tomás Pascual,Benedetta Conte,Benedetta Conte,Olga Martínez-Sáez,Olga Martínez-Sáez,Barbara Adamo,Barbara Adamo,Maria Vidal,Maria Vidal,Esther Barnadas,Aranzazu Fernandez-Martinez,Blanca Gonzalez-Farre,Blanca Gonzalez-Farre,Esther Sanfeliu,Esther Sanfeliu,Juan Miguel Cejalvo,Giuseppe Perrone,Giovanna Sabarese,Francesca Zalfa,Vicente Peg,Roberta Fasani,Patricia Villagrasa,Joaquín Gavilá,Carlos H. Barrios,Ana Lluch,Miguel Martín,Mariavittoria Locci,Sabino De Placido,Aleix Prat +35 more
TL;DR: In this article, the authors collected retrospective clinicopathological and PAM50 data from 3,689 patients with HER2-negative disease and made the following observations: the proportion of HER2low was higher in HR-positive disease (65.4%) than triple-negative BC (TNBC, 36.6%).
Journal ArticleDOI
Fragile X mental retardation protein (FMRP) binds specifically to the brain cytoplasmic RNAs BC1/BC200 via a novel RNA-binding motif.
Francesca Zalfa,Salvatore Adinolfi,Ilaria Napoli,Eva Kühn-Hölsken,Henning Urlaub,Tilmann Achsel,Annalisa Pastore,Claudia Bagni +7 more
TL;DR: It is demonstrated that the N terminus of FMRP binds strongly and specifically to BC1 and to its potential human analog BC200, raising the possibility that FMRp plays a direct role in BC1/mRNA annealing.