F
Francesco Cipollone
Researcher at University of Chieti-Pescara
Publications - 228
Citations - 9635
Francesco Cipollone is an academic researcher from University of Chieti-Pescara. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 49, co-authored 195 publications receiving 8335 citations. Previous affiliations of Francesco Cipollone include University of Rome Tor Vergata & University of Messina.
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Journal ArticleDOI
Receptor for advanced glycation end-products (RAGE) and soluble RAGE (sRAGE): cardiovascular implications.
TL;DR: The purpose of this review is to provide an overview of the present understanding of RAGE and sRAGE, their plausible role linking perturbed glucose metabolism with the development, progression and instability of atherosclerosis, and the potential therapeutic implications of modulation of this biological system.
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Balance Between PGD Synthase and PGE Synthase Is a Major Determinant of Atherosclerotic Plaque Instability in Humans
Francesco Cipollone,Maria Fazia,Annalisa Iezzi,Giovanni Ciabattoni,Barbara Pini,Chiara Cuccurullo,Sante Ucchino,Francesco Spigonardo,Mariella De Luca,Cesaria Prontera,Francesco Chiarelli,Franco Cuccurullo,Andrea Mezzetti +12 more
TL;DR: Results suggest that COX-2 may have proinflammatory and antiinflammatory properties as a function of expression of downstream PGH2 isomerases, and that the switch from L-PGDS to mPGES-1 in plaque macrophages is associated with cerebral ischemic syndromes, possibly through MMP-induced plaque rupture.
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Enhanced soluble CD40 ligand contributes to endothelial cell dysfunction in vitro and monocyte activation in patients with diabetes mellitus: effect of improved metabolic control
Francesco Cipollone,Francesco Chiarelli,Giovanni Davì,Claudio Ferri,Giovambattista Desideri,Maria Fazia,Annalisa Iezzi,Francesca Santilli,Barbara Pini,Chiara Cuccurullo,Stefano Tumini,A. Del Ponte,Anna Santucci,Franco Cuccurullo,Andrea Mezzetti +14 more
TL;DR: Upregulation of sCD40L as a consequence of persistent hyperglycaemia in diabetic patients results in EC activation and monocyte recruitment to the arterial wall, possibly contributing to accelerated atherosclerosis development in diabetes.
Journal ArticleDOI
Thromboxane-dependent CD40 ligand release in type 2 diabetes mellitus.
Francesca Santilli,G. Davi,Agostino Consoli,Francesco Cipollone,Andrea Mezzetti,Angela Falco,T. Taraborelli,E Devangelio,Giovanni Ciabattoni,Stefania Basili,Carlo Patrono +10 more
TL;DR: This study provides several lines of evidence for the dependence of sCD40L release on TXA(2)-dependent plateletactivation in T2DM and provides novel mechanistic insight into the amplification loops of persistent platelet activation in this setting.
Journal ArticleDOI
Association between prostaglandin E receptor subtype EP4 overexpression and unstable phenotype in atherosclerotic plaques in human.
Francesco Cipollone,Maria Fazia,Annalisa Iezzi,Chiara Cuccurullo,Domenico De Cesare,Sante Ucchino,Francesco Spigonardo,Antonio Marchetti,Fiamma Buttitta,L. Paloscia,Marco Mascellanti,Franco Cuccurullo,Andrea Mezzetti +12 more
TL;DR: This study shows that EP4 overexpression is associated with enhanced inflammatory reaction in atherosclerotic plaques, which might contribute to plaque destabilization by inducing culprit metalloproteinase expression.