Francis R. Carbone

TL;DR: Delivery of soluble OVA by both electroporation and commercial liposomes proved more efficient than osmotic loading in sensitising for class I presentation and provides a simple and efficient way of studying class I-restricted T cell recognition of soluble protein antigens.

TL;DR: It is shown that while P. berghei‐expressed antigens were presented early in infection, there was a rapid decline in presentation within 4 days, paralleling impairment in MHC class I‐ and II‐restricted presentation of third party antIGens, providing important evidence that P.berghei not only causes immunosuppression to subsequently encountered third partyAntigens, but also rapidly limits the capacity to generate effective parasite‐specific immunity.

TL;DR: Although lymph node CD8+ T cell numbers increase as a consequence of HSV infection, the majority of these cells are small resting cells that are not enriched for gB‐specific receptors, which is consistent with a nonspecific migration of CTL precursors into the lymph nodes draining the site of infection.

TL;DR: Uric acid released by damaged cells is a danger signal that is able to notify immune cells of microbial attack and alert the immune system to invading microorganisms.

TL;DR: It is indicated that vigorous CTL responses can be induced to pathogens even when they largely reside in red blood cells, which lack MHC I processing machinery.