F
Francis R. Carbone
Researcher at University of Melbourne
Publications - 216
Citations - 37352
Francis R. Carbone is an academic researcher from University of Melbourne. The author has contributed to research in topics: Cytotoxic T cell & T cell. The author has an hindex of 83, co-authored 213 publications receiving 35098 citations. Previous affiliations of Francis R. Carbone include Cooperative Research Centre & Washington University in St. Louis.
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Journal ArticleDOI
The Cytotoxic T-Cell Response to Herpes Simplex Virus Type 1 Infection of C57BL/6 Mice Is Almost Entirely Directed against a Single Immunodominant Determinant
TL;DR: Overall, HSV-1 infection of C57BL/6 mice results in an extremely focused pattern of CD8+ T-cell selection in terms of target specificity and TCR expression.
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Transfer of antigen between migrating and lymph node-resident DCs in peripheral T-cell tolerance and immunity
TL;DR: Evidence that antigen presentation can extend to DCs that permanently reside within the lymph node is described in the context of antigen transfer between migrating and lymphoid-resident DCs in cases of T-cell priming and tolerance induction.
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Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by bim
Gayle M. Davey,Christian Kurts,Jacques F. A. P. Miller,Philippe Bouillet,Andreas Strasser,Andrew G. Brooks,Francis R. Carbone,William R. Heath +7 more
TL;DR: The molecular basis of cross-tolerance was investigated and Bim, a pro-apoptotic Bcl-2 family member whose function can be inhibited by B cl-2, was found to play a critical role in the deletion of autoreactive thymocytes, leading us to examine its role in cross-Tolerance.
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MHC Class II Expression Is Regulated in Dendritic Cells Independently of Invariant Chain Degradation
Jose A Villadangos,Marı́a Cardoso,Raymond J. Steptoe,Dionne van Berkel,Joanne Pooley,Francis R. Carbone,Ken Shortman +6 more
TL;DR: Investigating the mechanisms that control MHC class II (MHC II) expression in immature and activated dendritic cells grown from spleen and bone marrow precursors found that late after activation, DC downregulated MHC II synthesis both in vitro and in vivo.
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Herpes Simplex Virus-Specific CD8+ T Cells Can Clear Established Lytic Infections from Skin and Nerves and Can Partially Limit the Early Spread of Virus after Cutaneous Inoculation
Allison L. van Lint,Margaret Ayers,Andrew G. Brooks,Richard M. Coles,William R. Heath,Francis R. Carbone +5 more
TL;DR: The role of CD8+ T cells during the normal course of disease is to clear replicating virus after infection is well established rather than limit the initial spread of HSV from the primary site of inoculation.