F
Francis R. Carbone
Researcher at University of Melbourne
Publications - 216
Citations - 37352
Francis R. Carbone is an academic researcher from University of Melbourne. The author has contributed to research in topics: Cytotoxic T cell & T cell. The author has an hindex of 83, co-authored 213 publications receiving 35098 citations. Previous affiliations of Francis R. Carbone include Cooperative Research Centre & Washington University in St. Louis.
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Journal ArticleDOI
Runx3 drives a CD8+ T cell tissue residency program that is absent in CD4+ T cells
Raissa Fonseca,Thomas N. Burn,Luke C. Gandolfo,Sapna Devi,Simone L Park,Andreas Obers,Maximilien Evrard,Susan N Christo,Frank Buquicchio,Caleb A. Lareau,Keely M McDonald,Sarah Sandford,Natasha Zamudio,Nágela Ghabdan Zanluqui,Ali Mohammed Abo Zaid,Terence P. Speed,Ansuman T. Satpathy,Scott N. Mueller,Francis R. Carbone,Laura K. Mackay +19 more
TL;DR: In this article , the authors show that the transcription factor Runx3 is a critical regulator of tissue residency in CD8+ T cell tissue residency, but its expression is repressed in CD4+ T cells.
Journal ArticleDOI
Peptide-induced deletion of CD8 T cells in vivo occurs via apoptosis in situ.
TL;DR: It is shown that the OT-I cells undergo proliferation and apoptosis in situ in lymphoid organs in response to antigenic stimulation with no evidence for liver involvement, which counters the view that the liver is a general site for CD8+ T cell clearance following antigen-specific activation.
Journal ArticleDOI
Phase Delay of the Rhythm of 6‐Sulphatoxy Melatonin Excretion by Artificial Light
TL;DR: The results demonstrate the inhibitory action of high intensity light in humans suggest that one 6‐h period of extra light in the evening can phase delay the melatonin onset.
Journal ArticleDOI
Inhibition of naïve class I-restricted T cells by altered peptide ligands.
TL;DR: Peptides with substitutions at TCR contact residues were found to be the most potent antagonists of OT‐I cell function and inhibition was inversely correlated with interferon (IFN)‐γ production.
Journal Article
Functional mapping of the orientation for TCR recognition of an H2-Kb-restricted ovalbumin peptide suggests that the beta-chain subunit can dominate the determination of peptide side chain specificity.
TL;DR: Functional data for TCR recognition of the H2-Kb class-I restricted determinant derived from OVA that are consistent with the TCR orientation defined by these crystal structures are presented and the beta-chain CDR3 dominates side chain specificity for the most exposed regions within this peptide.