F
Francis R. Carbone
Researcher at University of Melbourne
Publications - 216
Citations - 37352
Francis R. Carbone is an academic researcher from University of Melbourne. The author has contributed to research in topics: Cytotoxic T cell & T cell. The author has an hindex of 83, co-authored 213 publications receiving 35098 citations. Previous affiliations of Francis R. Carbone include Cooperative Research Centre & Washington University in St. Louis.
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Journal ArticleDOI
The CD8α+ Dendritic Cell Is Responsible for Inducing Peripheral Self-Tolerance to Tissue-associated Antigens
Gabrielle T. Belz,Georg M N Behrens,Caleb Smith,Jacques F. A. P. Miller,Claerwen M. Jones,Kristina Lejon,C. Garrison Fathman,Scott N. Mueller,Ken Shortman,Francis R. Carbone,William R. Heath +10 more
TL;DR: It is indicated that CD8α+ DCs play a critical role in both tolerance and immunity to cell-associated antigens, providing a potential mechanism by which cytotoxic T lymphocyte can be immunized to viral antigen while maintaining tolerance to self.
Journal ArticleDOI
Dendritic cell-induced memory T cell activation in nonlymphoid tissues.
Linda M. Wakim,Jason Waithman,Jason Waithman,Jason Waithman,Nico van Rooijen,Nico van Rooijen,Nico van Rooijen,William R. Heath,William R. Heath,William R. Heath,Francis R. Carbone,Francis R. Carbone,Francis R. Carbone +12 more
TL;DR: Results revealed that memory CD8+ T cell responses can be initiated within peripheral tissues through a tripartite interaction that includes CD4+ T cells and recruited dendritic cells, lending evidence for the existence of a sophisticated T cell response mechanism in extra-lymphoid tissues that can act to control localized infection.
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The dominant role of CD8+ dendritic cells in cross-presentation is not dictated by antigen capture
Petra Schnorrer,Georg M. N. Behrens,Nicholas S. Wilson,Joanne Pooley,Christopher M. Smith,Dima El-Sukkari,Gayle M. Davey,Fiona Kupresanin,Ming Li,Eugene Maraskovsky,Gabrielle T. Belz,Francis R. Carbone,Ken Shortman,William R. Heath,Jose A Villadangos +14 more
TL;DR: Mouse spleens contain three populations of conventional (CD11c(high)) dendritic cells (DCs) that play distinct functions, and results indicate that cross-presentation requires specialized machinery that is expressed by CD8(+) DC but largely absent fromCD8(-) DC.
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Cognate CD4+ T cell licensing of dendritic cells in CD8+ T cell immunity
Christopher M. Smith,Nicholas S. Wilson,Jason Waithman,Jose A Villadangos,Francis R. Carbone,William R. Heath,Gabrielle T. Belz +6 more
TL;DR: It is shown here that help is essential for the generation of CTL immunity to herpes simplex virus 1 and that CD4+ T cells mediate help in a cognate, antigen-specific way and that C TL immunity may be heavily dependent on cognate DC licensing.
Journal ArticleDOI
Dendritic cell subsets in primary and secondary T cell responses at body surfaces
TL;DR: This work examines the role of dendritic cells subsets in immunity to peripheral infections, with emphasis on the differences in the regulation of primary and secondary T cell responses to viruses.